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AB947

Sigma-Aldrich

Anti-Apolipoprotein E Antibody

serum, Chemicon®

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Synonym(s):
ApoE
eCl@ss:
32160702
NACRES:
NA.41

biological source

goat

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

primate, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

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This Item
AB742SAB2500092SAB2502171
Sigma-Aldrich

AB947

Anti-Apolipoprotein E Antibody

Sigma-Aldrich

AB742

Anti-Apolipoprotein B Antibody

antibody form

serum

antibody form

serum

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

technique(s)

indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P02649

UniProt accession no.

P04114

UniProt accession no.

Q13790

UniProt accession no.

P02647

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

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Specificity

Monospecific for Apolipoprotein E by immunoelectrophoresis when tested against pooled human plasma and twice concentrated pooled human serum. Reacts with Apo E isoforms E2, E3 and E4 by Western blot.

Immunogen

Recombinant human apolipoprotein E.

Application

Detect Apolipoprotein E using this Anti-Apolipoprotein E Antibody validated for use in IH & WB.
Research Category
Metabolism
Research Sub Category
Lipid Metabolism & Weight Regulation
Western blot (Schwab, 1996): 1:1,000-1:2,000

Immunohistochemistry (Summers, 1998; Wisniewski & Frangione, 1992; Schwab, 1996)

Optimal working dilutions must be determined by the end user.

Target description

34 kDa

Physical form

Delipidated goat antiSerum, 0.2 μm filtered. Liquid in Tris-saline, pH 7.4 with 0.1% sodium azide as preservative.
Unpurified

Storage and Stability

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Liver tissue

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Jianjia Fan et al.
PloS one, 11(9), e0162384-e0162384 (2016-09-07)
The apolipoprotein E (APOE) gene is the most highly associated susceptibility locus for late onset Alzheimer's Disease (AD), and augmenting the beneficial physiological functions of apoE is a proposed therapeutic strategy. In a high throughput phenotypic screen for small molecules
Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.
Lord, A; Philipson, O; Klingstedt, T; Westermark, G; Hammarstrom, P; Nilsson, KP; Nilsson, LN
The American Journal of Pathology null
The association of hepatitis C virus glycoproteins with apolipoproteins E and B early in assembly is conserved in lipoviral particles.
Boyer, A; Dumans, A; Beaumont, E; Etienne, L; Roingeard, P; Meunier, JC
The Journal of Biological Chemistry null
Differential regulation of amyloid-? endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.
Li, J; Kanekiyo, T; Shinohara, M; Zhang, Y; LaDu, MJ; Xu, H; Bu, G
The Journal of Biological Chemistry null
Ronald D Gorham et al.
Journal of medicinal chemistry, 58(2), 814-826 (2014-12-11)
Compstatin peptides are complement inhibitors that bind and inhibit cleavage of complement C3. Peptide binding is enhanced by hydrophobic interactions; however, poor solubility promotes aggregation in aqueous environments. We have designed new compstatin peptides derived from the W4A9 sequence (Ac-ICVWQDWGAHRCT-NH2

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