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ABT121

Sigma-Aldrich

Anti-T-cadherin (CDH13) Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
Cadherin-13, Heart cadherin, H-cadherin, P105, Truncated cadherin, T-cad, T-cadherin
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

horse, human, rat

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), bovine (based on 100% sequence homology), equine (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CDH13(1012)

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SAB4200672C1821SAB1300555
vibrant-m

ABT121

Anti-T-cadherin (CDH13) Antibody

biological source

rabbit

biological source

mouse

biological source

mouse

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

affinity isolated antibody

species reactivity

horse, human, rat

species reactivity

human

species reactivity

canine, frog, snake, guinea pig, chicken, pig, feline, bovine, rabbit, hamster, Psammomys (sand rat), goat, rat, human, sheep, mouse

species reactivity

human

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

immunoblotting: 5-10 μg/mL using whole extract of human HeLa cells., immunohistochemistry: 5-10 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human heart sections, immunoprecipitation (IP): 5-10 μg/mL using whole extract of human HeLa cells.

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using protease-digested animal heart sections, indirect immunofluorescence: 1:500 using cultured MDBK cells, microarray: suitable, western blot: suitable

technique(s)

indirect ELISA: 1:1000, western blot: 1:100-1:500

clone

polyclonal

clone

CAD-5, monoclonal

clone

CH-19, monoclonal

clone

polyclonal

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General description

T-cadherin (CDH13), also known as Cadherin 13, is a member of the cadherin superfamily. This protein is unique from its other family members in that it lacks the cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. T-cadherin is widely expressed in the cardiovascular system. Mutations in T-cadherin have been associated with many types of cancer.

Specificity

This antibody recognizes T-cadherin at the Cadherin 1 domain. This antibody detects the ~130 kDa pro-protein and the proteolytically cleaved ~105 kDa mature isoforms. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)

Immunogen

Epitope: Cadherin 1 domain
KLH-conjugated linear peptide corresponding to human T-cadherin at the Cadherin 1 domain.

Application

Anti-T-cadherin (CDH13) Antibody detects level of T-cadherin (CDH13) & has been published & validated for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected T-cadherin in human brain and human heart tissues.
Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)

Quality

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected T-cadherin on 10 µg of human heart tissue lysate.

Target description

~130 and ~105 kDa observed.
~130 kDa corresponds to the pro-protein and ~105 kDa corresponds to the proteolytically cleaved mature isoform. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.)

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Human heart tissue lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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