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CC4000

Sigma-Aldrich

Urokinase-type Plasminogen Activator

Synonym(s):

uPA

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41

biological source

human

Quality Level

assay

>98% (SDS-PAGE)

form

solid

manufacturer/tradename

ChemiconĀ®

technique(s)

activity assay: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

human ... PLAU(5328)

General description

A thrombolytic agent that converts plasminogen to plasmin. A mixture of high molecular weight and low molecular weight urokinase.
Product Source: Prepared from urine of healthy individuals

Physical form

Lyophilized from 200 mM manitol, 100 mM NaCl, 50 mM Tris-HCl, pH 7.5 and 0.1 % PEG.

Storage and Stability

Reconstitute using 200-400 Ī¼L dH2O. Store at -20Ā°C. Following reconstitution, aliquot and freeze (-70Ā°C). This product is stable for 2 year as supplied. Stock solutions are stable for up to 6 months at -70Ā°C.

Analysis Note

High molecular weight urokinase (54 kD): 40%.Low molecular weight urokinase (33 kD): 50%.Transitory forms of urokinase: 10%

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


Certificates of Analysis (COA)

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Thrombolytic therapy: a comparison between urokinase and streptokinase. From a national cooperative study.
W R Bell
Seminars in thrombosis and hemostasis, 2(1), 1-13 (1975-07-01)
Assay methods and standard preparations for plasmin, plasminogen and urokinase in purified systems, 1967-1968.
Johnson, A J, et al.
Thrombosis et Diathesis Haemorrhagica, 21, 259-272 (1969)
Sean T Zuckerman et al.
Biomaterials, 30(23-24), 3825-3833 (2009-05-16)
Mass spectrometry is a powerful proteomic tool enabling researchers to survey the global proteome of a cell. This technique has only recently been employed to investigate cell-material interactions. We had previously identified material scarcity and limited adherent cells as challenges

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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