SRP6518

Plasminogen from human plasma

≥95% (SDS-PAGE)

• Synonym(s): PLG
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: human
• assay: ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: 90.0 – 92.0 kDa
• packaging: pkg of 1 mg
• UniProt accession no.: P00747
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... PLG(5340)

Description

General description

Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.[1]
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27.[2] The encoded protein is characterized with a leader, kringle and protease domains.[3]

Biochem/physiol Actions

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa.[1] It activates matrix metalloproteinases by cleaving the inactive proenzymes.[4] Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).[5][6]

Physical form

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable