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GF439-M

Sigma-Aldrich

HumanKine® TGF beta 1, Human Recombinant Xeno-Free

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Synonym(s):
TGFB, TGFb1, Transforming Growth Factor-β1
eCl@ss:
32160405

assay

>95% (SDS-PAGE)

Quality Level

manufacturer/tradename

HumanKine®

impurities

<0.1 μg/mg protein endotoxin (1 EU/μg)

UniProt accession no.

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GF446-MGF446GF414-M
impurities

<0.1 μg/mg protein endotoxin (1 EU/μg)

impurities

<0.5 μg/mg protein endotoxin (<5 EU/μg)

impurities

<0.5 μg/mg protein endotoxin (<5 EU/μg)

impurities

<0.1 μg/mg protein endotoxin (1 EU/μg)

UniProt accession no.

P01137

UniProt accession no.

P09038

UniProt accession no.

P09038

UniProt accession no.

P14210

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

HumanKine®

manufacturer/tradename

-

manufacturer/tradename

HumanKine®

manufacturer/tradename

HumanKine®

General description

HumanKine growth factors are expressed in a proprietary human 293 protein expression system and are manufactured without the use of any animal products and are considered Xeno-Free.
Transforming growth factor beta (TGF-B) is a multifunctional cytokine that controls proliferation, differentiation, and other functions in many cell types. TGF-B acts synergistically with TGF-A in inducing transformation. It also acts as a negative autocrine growth factor. TGF-B regulates the actions of many other growth factors and determines a positive or negative direction of their effects. It plays an important role in bone remodeling. It is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

Application

Research Category
Stem Cell Research
Research Sub Category
Growth Factors & Receptors

Quality

Bioactivity assay: Determined by the dose dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2). ED50 is typically 0.1-0.5 ng/ml.

Physical form

Product is presented in 50mM NaOAc pH 4.5 and filtered through a 0.2 micron filter before lyophilization.

Preparation Note

HumanKine TGF beta1 is manufactured using all non-animal reagents and is considered Xeno-Free

Storage and Stability

Store at -20°C for up to 4 months from date of receipt. Further dilutions should be made into appropriate buffer or medium to which protein has been added.

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1


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