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MAB2014

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Anti-OB-Cadherin Antibody, extracellular domain, clone 16A

clone 16A, Chemicon®, from mouse

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Synonym(s):
Cadherin-11
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

16A, monoclonal

species reactivity

rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CDH11(1009)

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MABF3160MABT26SAB5500022
clone

16A, monoclonal

clone

8C11, monoclonal

clone

Decma-1, monoclonal

clone

SP64, monoclonal

Gene Information

human ... CDH11(1009)

Gene Information

human ... CHD2(1000)

Gene Information

human ... CDH1(999)
mouse ... Cdh1(12550)

Gene Information

human ... CDH1(999)

biological source

mouse

biological source

mouse

biological source

rat

biological source

rabbit

species reactivity

rat, human

species reactivity

hamster, human

species reactivity

human, mouse

species reactivity

human (tested)

isotype

IgG1

isotype

IgG1κ

isotype

IgG1κ

isotype

IgG

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General description

Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. The progression of carcinomas is associated with the loss of epithelial morphology and a concomitant acquisition of a more mesenchymal phenotype, which is thought to contribute to the invasive and/or metastatic behavior. A putative role for cadherin-11 in these late stages of tumor progression is based on the fact that migration of mesenchymal cells is facilitated when cadherin-11 is highly expressed.

Specificity

Reacts with the extracellular domain of human cadherin-11.

Immunogen

Epitope: extracellular domain
Fusion protein corresponding to extracellular domain of human OB-cadherin coupled to GST.

Application

Detect OB-Cadherin using this Anti-OB-Cadherin Antibody, extracellular domain, clone 16A validated for use in WB, IC, IH.
Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)
Western blot: 1:25 - 1:250
Immunohistochemistry: Frozen tissue sections. 1:25 - 1:50 dilution using avidin-biotinylated horseradish peroxidase complex (ABC) as detection protocol.
Immunocytochemistry: Methanol and paraformaldehyde-fixed cells
Optimal working dilutions must be determined by the end user.I/

Physical form

Affinity purified immuoglobulin. Liquid in PBS containing 0.09% sodium azide.
Format: Purified

Storage and Stability

1 year at 4°C from date of shipment

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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