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MAB4350

Sigma-Aldrich

Anti-BMP-7 Antibody, clone 2A10

clone 2A10, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

2A10, monoclonal

species reactivity

mouse, human

technique(s)

immunohistochemistry: suitable
western blot: suitable

input

sample type mesenchymal stem cell(s)

isotype

IgG1κ

UniProt accession no.

P18075

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... BMP7(655)
mouse ... Bmp7(12162)

General description

Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder.

Specificity

Reactivity with other species has not been tested.

Application

Immunohistochemistry: Recommended working dilution is 1:50.

Western Blotting: Recommended working concentration is 1 – 2 µg/mL.
This Anti-BMP-7 Antibody, clone 2A10 is validated for use in WB, IH for the detection of BMP-7.

Target description

46 kDa

Physical form

Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4),
150 mM NaCl, and 0.05% sodium azide.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Oral administration of recombinant adeno-associated virus-mediated bone morphogenetic protein-7 suppresses CCl(4)-induced hepatic fibrosis in mice.
Hao, ZM; Cai, M; Lv, YF; Huang, YH; Li, HH
Molecular Therapy null
Rongrong Zhang et al.
Communications biology, 7(1), 266-266 (2024-03-05)
Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5 plays in activating hepatic stellate cells (HSCs) and liver fibrosis. In this study, SNHG5 was
Ariadne Cristiane Cabral Cruz et al.
Journal of applied oral science : revista FOB, 20(6), 628-635 (2013-01-19)
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. This study evaluated the effect of a recombinant BMP-2 as well as the
Ariadne Cristiane Cabral Cruz et al.
Journal of applied oral science : revista FOB, 27, e20180317-e20180317 (2019-02-28)
Bone morphogenetic protein type 2 (BMP-2) and retinoic acid (RA) are osteoinductive factors that stimulate endogenous mechanisms of bone repair which can be applied on management of osseous defects in oral and maxillofacial fields. Considering the different results of RA

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