MABC288

Anti-Folliculin (FLCN), Antibody clone 8D9.2

clone 8D9.2, from mouse

• Synonym(s): Folliculin, BHD skin lesion fibrofolliculoma protein, Birt-Hogg-Dube syndrome protein, Folliculin (FLCN)
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 8D9.2, monoclonal
• species reactivity: human
• technique(s): immunocytochemistry: suitable; western blot: suitable
• isotype: IgMκ
• NCBI accession no.: NP_653207
• UniProt accession no.: Q8NFG4
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... FLCN(201163)

Description

General description

Folliculin (FLCN) is a protein with many possible roles. Folliculin may play a role in the pathogenesis of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). But, Folliculin (FLCN) may be a tumor suppressor, however it is also involved in the generation of colorectal tumorigenesis and renal cell carcinoma, and finally Folliculin (FLCN) might be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. Mutations of Folliculin (FLCN) give rise to Birt-Hogg-Dube syndrome, a rare autosomal dominant genodermatosis characterized by hair follicle hamartomas (fibrofolliculomas), kidney tumors, and spontaneous pneumothorax disorders. Folliculin (FLCN) is widely expressed and localized in both the cytoplasm and nucleus depending upon the conditions in both the fetus and the adult.

Immunogen

GST-tagged recombinant protein corresponding to human Folliculin (FLCN).

Application

Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected Folliculin (FLCN) in HeLa cells.
Alexa Fluor^™ is a registered trademark of Life Technologies.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-Folliculin (FLCN), Antibody clone 8D9.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of Folliculin (FLCN).

Quality

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Folliculin (FLCN) in 10 µg of HeLa cell lysate.

Target description

~65 kDa observed.

Physical form

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable