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MABN481

Sigma-Aldrich

Anti-Lipocalin-2 Antibody, clone PA348-26.3.5

clone PA348-26.3.5, from mouse

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Synonym(s):
ngal, neutrophil lipocalin, siderocalin, Neutrophil gelatinase-associated lipocalin, NGAL, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

PA348-26.3.5, monoclonal

species reactivity

human

technique(s)

ELISA: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... LCN2(3934)

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This Item
AB2267SAB2500595HPA002695
Anti-LCN2 Antibody from rabbit, purified by affinity chromatography

AB2267

Anti-LCN2 Antibody

Gene Information

human ... LCN2(3934)

Gene Information

human ... LCN2(3934)

Gene Information

human ... LCN2(3934)

Gene Information

human ... LCN2(3934)

biological source

mouse

biological source

rabbit

biological source

goat

biological source

rabbit

clone

PA348-26.3.5, monoclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

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General description

Lipocalin-2 (LCN2) (also known as Neurophil Gelatinase-Associated Lipocalin or NGAL) belongs to a superfamily of lipocalins, a collection of small, diversely functional, extracellular proteins. Lipocalin-2 is secreted from neutrophil granules in three different forms: a monomer of 25 kDa, a disulfide-linked homodimer at 46 kDa, and a disulfide-linked heterodimer with MMP-9 at 135-kDa. It is widely known to induce development of kidney epithelia, to bind and traffic iron, and to act as a molecular signal under inflammatory conditions, such as Crohn’s Disease. Multiple carcinoma studies have also shown elevated expression levels of Lipocalin-2 in several different human tumors affecting such organs as colon, lung, breast, ovaries, and pancreas. Additionally, there has been great interest in this protein as a possible marker for onset of Acute Kidney Injury following cardiac surgery, the progression of Chronic Kidney Disease (CKD), and the survival chances of patients with Chronic Heart Failure (CHF).

Immunogen

Recombinant protein corresponding to human Lipocalin-2.

Application

Detect Lipocalin using this mouse monoclonal antibody, Anti-Lipocalin-2 Antibody, clone PA348-26.3.5 validated for use in western blotting, IHC & ELISA.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Lipoacalin-2 in human bone marrow and stomach tissue lysate.

ELISA Analysis: A representative lot from an independent laboratory detected Lipocalin-2 in indirect ELISA.
Research Category
Neuroscience
Research Sub Category
Neurodegenerative Diseases

Quality

Evaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Lipocalin-2 in 10 µg of human lung tissue lysate.

Target description

~23 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Ting Wei et al.
Scientific reports, 6, 24378-24378 (2016-04-15)
Extracranial arteriovenous malformations (AVMs) are rare but dangerous congenital lesions arising from direct arterial-venous shunts without intervening capillaries. Progressive infiltration, expansion, and soft tissue destruction lead to bleeding, pain, debilitation and disfigurement. The pathophysiology of AVMs is not well understood.

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