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MABT61

Sigma-Aldrich

Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302

clone R1.302.12, from mouse

Synonym(s):

poliovirus receptor-related 1 (herpesvirus entry mediator C), nectin-1, poliovirus receptor-related protein 1, poliovirus receptor-like 1, nectin 1, ectodermal dysplasia 4 (Margarita Island type), Herpesvirus entry mediator C, Herpes virus entry mediator

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50 μG
$411.00

$411.00


Estimated to ship onMarch 28, 2025


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50 μG
$411.00

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

clone:
R1.302.12, monoclonal
application:
FACS
IF
species reactivity:
human
technique(s):
flow cytometry: suitable
immunofluorescence: suitable
citations:
1

$411.00


Estimated to ship onMarch 28, 2025


Request a Bulk Order

biological source

mouse

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

R1.302.12, monoclonal

species reactivity

human

technique(s)

flow cytometry: suitable
immunofluorescence: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

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This Item
SAB4200370SAB4200369HPA011038
biological source

mouse

biological source

mouse

biological source

mouse

biological source

rabbit

species reactivity

human

species reactivity

human

species reactivity

rat, human, monkey, mouse

species reactivity

human

clone

R1.302.12, monoclonal

clone

N4.101.10, monoclonal

clone

R2.5254.2, monoclonal

clone

polyclonal

Gene Information

human ... PVRL1(5818)

Gene Information

human ... PVRL4(81607)

Gene Information

human ... NECTIN2(5819), PVRL2(5819), PVRL2(308417)
mouse ... Nectin2(19294)

Gene Information

human ... PVRL3(25945)

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

General description

Nectin-1, also known as poliovirus receptor-related protein 1 (PRR1 or PVRL1) or CD111, is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectins are known for being the receptors for the herpes simplex virus. Nectin-1 is connected with the actin cytoskeleton through afadin inside the cell. It is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-1 seems to adhere primarily to cells expressing nectin-4 and vice versa.

Immunogen

Human CD111 transfected NIH/3T3 cells

Application

Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Cocchi, F., et al. (1998). Journal of Virology. 72(12):9992–10002).
This Anti-Nectin-1/PVRL1 (CD111) Antibody, clone R1.302 is validated for use in FC, IF for the detection of Nectin-1/PVRL1 (CD111).

Quality

Evaluated by Flow Cytometry in human TF-1 cells.

Flow Cytometry Analysis: 0.25 µg of this antibody detected Nectin-1/PVRL1 in human TF-1 cells.

Target description

57 kDa calculated

Physical form

Format: Purified

Analysis Note

Control
Human TF-1 cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Kristin L M Boylan et al.
Oncotarget, 8(6), 9717-9738 (2016-12-31)
The cell adhesion molecule Nectin-4 is overexpressed in epithelial cancers, including ovarian cancer. The objective of this study was to determine the biological significance of Nectin-4 in the adhesion, aggregation, migration, and proliferation of ovarian cancer cells. Nectin-4 and its

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