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SCC163

Sigma-Aldrich

HOG Human Oligodendroglioma Cell Line

HOG human oligodendroglioma cell line is a useful model to study the role of oligodendrocytes in neurodegenerative diseases.

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Synonym(s):
Oligodendroglioma cells
eCl@ss:
32011203

biological source

human

technique(s)

cell based assay: suitable
cell culture | mammalian: suitable

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SCC150SCC210SCC415
technique(s)

cell based assay: suitable, cell culture | mammalian: suitable

technique(s)

cell based assay: suitable, cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

General description

HOG is a clonal cell line derived from a surgically removed human oligodendroglioma (HOG) . HOG cells express oligodendrocyte markers including low levels of the 15-kDa form of myelin basic protein (MBP) and high levels of CNPase protein. HOG cells do not express GFAP, a astrocyte marker and were found to have minimal levels of glutamine synthetase activity . HOG cells express neurotransmitter receptors such as A2-adenosine, prostaglandin E1 (PGE1) and beta2-adrenergic receptores (beta-ARs) that activate the adenylate cylase signaling pathway . HOG cells also express muscarinic and histamine receptors that are linked to inositol phosphate signaling pathways .

Cell Line Description

Cancer Cells

Application

Research Category
Neuroscience
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Quality

• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, C, and HIV-1 & 2 viruses as assessed by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

Storage and Stability

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Suixin Liang et al.
Neuropsychiatric disease and treatment, 19, 1625-1631 (2023-07-24)
Moderate therapeutic hypothermia is protective against several cellular stressors. However, the mechanisms behind this protection are not entirely known. In the current investigation, we investigated that therapeutic hypothermia at 33°C administered following peroxide-induced oxidative stress might protect human oligodendroglioma cells
Lynn Vitale-Cross et al.
EBioMedicine, 78, 103981-103981 (2022-04-08)
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections result in the temporary loss of smell and taste in about one third of confirmed cases. We used immunohistochemistry to confirm the presence of ACE2, NRP1 and TMPRSS2 in two cranial nerves (IX
G R Post et al.
Molecular and chemical neuropathology, 16(3), 303-317 (1992-06-01)
A novel clonal cell line derived from a human glioma (HOG) was found to express some oligodendrocyte-specific proteins including a 15-kDa form of myelin basic protein (MBP) and high 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) activity. Expression of the myelin lipids galactosylceramide
Marta Merli et al.
Frontiers in bioengineering and biotechnology, 10, 1032542-1032542 (2023-01-10)
Introduction: In the view of 3D-bioprinting with cell models representative of neural cells, we produced inks to mimic the basic viscoelastic properties of brain tissue. Moving from the concept that rheology provides useful information to predict ink printability, this study
M Buntinx et al.
Journal of neurocytology, 32(1), 25-38 (2003-11-18)
Oligodendrocytes, the myelin-forming cells of the central nervous system, are the target of pathogenic immune responses in multiple sclerosis. Primary cultures of human oligodendrocytes have been used to unravel the cellular and molecular mechanisms of immune-mediated injury of oligodendrocytes. However

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