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10634425001

Roche

n-Octylglucoside

non-ionic

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Synonym(s):
Octyl β-D-glucopyranoside, n-Octyl glucoside, OGP
Empirical Formula (Hill Notation):
C14H28O6
CAS Number:
Molecular Weight:
292.37
Beilstein:
84118
MDL number:
PubChem Substance ID:

Assay

99% (GC)

mol wt

micellar avg mol wt 25,000
292.4

packaging

pkg of 10 g

manufacturer/tradename

Roche

aggregation number

84

technique(s)

dialysis: suitable

CMC

20-25 mM (20-25°C)

transition temp

cloud point >100 °C

shipped in

ambient

SMILES string

CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C14H28O6/c1-2-3-4-5-6-7-8-19-14-13(18)12(17)11(16)10(9-15)20-14/h10-18H,2-9H2,1H3/t10-,11-,12+,13-,14-/m1/s1

InChI key

HEGSGKPQLMEBJL-RKQHYHRCSA-N

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This Item
O3757O9882494459
n-Octylglucoside non-ionic

Roche

10634425001

n-Octylglucoside

-
Octyl β-D-glucopyranoside BioXtra, ≥98% (GC)

Sigma-Aldrich

O9882

Octyl β-D-glucopyranoside

Premium Grade
mol wt

micellar avg mol wt 25,000, 292.4

mol wt

average mol wt 24500-25000

mol wt

micellar avg mol wt 25,000

mol wt

-

aggregation number

84

aggregation number

84

aggregation number

84

aggregation number

84

technique(s)

dialysis: suitable

technique(s)

-

technique(s)

-

technique(s)

-

CMC

20-25 mM (20-25°C)

CMC

20-25

CMC

20-25 mM (20-25°C)

CMC

20 - 25 mM

transition temp

cloud point >100 °C

transition temp

cloud point ≥100

transition temp

cloud point >100 °C

transition temp

-

General description

1-O-n-Octyl-β-D-glucopyranoside, octylglucoside, is a detergent with an octyl chain as hydrophobic residue and glucose as hydrophilic part. It is a non-ionic, dialyzable, mild and non-denaturing detergent which is used for the solubilization, isolation and reconstitution of membrane proteins.

Application

N-Octylglucoside has been shown to increase the resolution of proteins in 2D gels. It is a mild and non-denaturing detergent for the solubilization and reconstitution of membrane proteins. N-Octylglucoside is easily removed by dialysis. N-Octylglucoside has been used in mass spectrometric immunoassay to homogenize MALDI (matrix assisted laser desorption/ionization) matrix draw and elution.
Non-ionic, dialyzable detergent for the solubilization and isolation of membrane proteins. Has been shown to increase the resolution of proteins in 2D gels.

Quality

Purity: 99% (from C), homogeneous (GC)

Ease of removal*: ++
CMC**: 14.5 mM at +25°C
Formula: C14H28O6

Preparation Note

Working concentration: 46 mM
Working solution: Solubility: > 50% (w/v) in double-dist. water, Tris-HCl 0.05 mol/l; pH7.4 or K-phosphate buffer 0.1 mol/l, pH 7.0 at 25 °C.
Storage conditions (working solution): Stability in Solution
A stock solution is stable at 2 to 8 °C for approx. 3 days. We would expect a long term stability of 6-12 months if stored frozen in portions at -15 to -25 °C, provided bacterial contamination is avoided.

Storage and Stability

Store at 15 to 25 °C. (Store dry!)

Other Notes

For life science research only. Not for use in diagnostic procedures.

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W A Petri et al.
The Journal of biological chemistry, 254(11), 4313-4316 (1979-06-10)
The glycoprotein of vesicular stomatitis (VS) virus was selectively liberated from the virion membrane by the dialyzable nonionic detergent, beta-D-octylglucoside. The isolated viral glycoprotein could be rendered virtually free of phospholipid and detergent, under which conditions it formed tail-to-tail glycoprotein
Howard R Mellor et al.
The Biochemical journal, 374(Pt 2), 307-314 (2003-05-29)
The N-alkyl moiety of N-alkylated imino sugars is crucial for therapeutic activities of these compounds as inhibitors of glycosphingolipid (GSL) biosynthesis and as antivirals. The improved potency afforded by a long N-alkyl moiety is coincident with increased compound-induced cytotoxicity. Therefore
Olgica Trenchevska et al.
Proteome science, 9(1), 19-19 (2011-04-12)
Post-translational modifications and genetic variations give rise to protein variants that significantly increase the complexity of the human proteome. Modified proteins also play an important role in biological processes. While sandwich immunoassays are routinely used to determine protein concentrations, they
Olgica Trenchevska et al.
Journal of proteome research, 9(11), 5969-5973 (2010-09-09)
Protein biomarkers are essential in assessing pathogenic processes. The impetus for finding new biomarkers has been accelerated by the arrival of the "omics" technologies. However, equally important is the rediscovery of existing biomarkers with these new approaches as novel variants

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