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D4641

Sigma-Aldrich

n-Dodecyl β-D-maltoside

≥98% (GC)

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Synonym(s):
DDM, Lauryl-β-D-maltoside
Empirical Formula (Hill Notation):
C24H46O11
CAS Number:
Molecular Weight:
510.62
Beilstein/REAXYS Number:
55318
MDL number:
eCl@ss:
32190102
PubChem Substance ID:
NACRES:
NA.25

biological source

corn

Quality Level

description

non-ionic

assay

≥98% (GC)

form

powder

mol wt

micellar avg mol wt 50,000

aggregation number

98

technique(s)

protein quantification: suitable

impurities

<1.5% water (Karl Fischer)

CMC

0.15 mM (20-25°C)

mp

224-226 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O

InChI

1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1

InChI key

NLEBIOOXCVAHBD-QKMCSOCLSA-N

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1 of 4

This Item
D5172324355D7658
vibrant-m

D4641

n-Dodecyl β-D-maltoside

-
vibrant-m

D5172

n-Dodecyl β-D-maltoside

Premium Grade
vibrant-m

324355

n-Dodecyl β-D-maltoside

-
vibrant-m

D7658

Decyl β-D-maltopyranoside

-
form

powder

form

powder

form

solid

form

powder

technique(s)

protein quantification: suitable

technique(s)

protein purification: suitable, protein quantification: suitable

technique(s)

-

technique(s)

-

aggregation number

98

aggregation number

98

aggregation number

98

aggregation number

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

mp

224-226 °C (lit.)

mp

224-226 °C (lit.)

mp

-

mp

-

General description

N-dodecyl-β-D-maltoside, also known as Lauryl Maltoside, stands as a non-ionic surfactant and derivative of pyrene (Py). Functioning as an alkyl maltopyranoside detergent, it excels particularly in the solubilization and crystallization of membrane proteins, making it a crucial tool in cell biology and biochemical research. Its unique capability arises from its adeptness at forming micelles that mimic the membrane environment, thereby preserving the α-helical structures and native conformations of membrane-associated proteins.

In addition to its primary function, N-dodecyl-β-D-maltoside has diverse applications, including the purification and stabilization of RNA polymerase, the detection of protein-lipid interactions, and serving as a substrate for glucosyl and xylosyl transfer by glycogenin. Its mild and non-denaturing properties have further led to its utilization in protein-anesthetic studies. Overall, N-dodecyl-β-D-maltoside emerges as a versatile detergent with a broad range of applications in membrane protein research and beyond. Its pivotal role in preserving protein structure and function establishes it as an indispensable tool for exploring the intricacies of membrane biology.

Application

Non-ionic detergent for the stabilization and activation of enzymes and for membrane research.
n-Dodecyl β-D-maltoside has been used in a study to assess the mapping of unfolding states of integral helical membrane proteins by GPS-NMR and scattering techniques.

Features and Benefits

  • Highly versatile surfactant for your cell biology and biochemical research
  • Suitable for protein quantification

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Protocols

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