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324355

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n-Dodecyl β-D-maltoside

ULTROL® Grade, ≥98% (HPLC), non-ionic detergent for the stabilization and activation of enzymes

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Synonym(s):
n-Dodecyl-β-D-maltoside, ULTROL® Grade, DDM, Dodecyl maltoside, Lauryl-β-D-maltoside
CAS Number:
MDL number:

Quality Level

assay

≥98% (HPLC)

form

solid

mol wt

micellar wt 50000

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

aggregation number

98

impurities

≤1% dodecanol 1H NMR

color

white

CMC

100-600 μM

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C24H46O11/c1-2-3-4-5-6-7-8-9-10-11-12-32-23-21(31)19(29)22(16(14-26)34-23)35-24-20(30)18(28)17(27)15(13-25)33-24/h15-31H,2-14H2,1H3/t15-,16-,17-,18+,19-,20-,21-,22-,23-,24-/m1/s1

InChI key

NLEBIOOXCVAHBD-QKMCSOCLSA-N

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This Item
D5172D4641252718
vibrant-m

324355

n-Dodecyl β-D-maltoside

-
vibrant-m

D5172

n-Dodecyl β-D-maltoside

Premium Grade
vibrant-m

D4641

n-Dodecyl β-D-maltoside

-
vibrant-m

252718

Decyl-β-D-maltopyranoside

-
assay

≥98% (HPLC)

assay

≥98% (GC)

assay

≥98% (GC)

assay

≥99% (HPLC)

aggregation number

98

aggregation number

98

aggregation number

98

aggregation number

-

mol wt

micellar wt 50000

mol wt

micellar avg mol wt 50,000

mol wt

micellar avg mol wt 50,000

mol wt

-

solubility

water: 100 mg/mL

solubility

-

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 100 mg/mL

CMC

100-600 μM

CMC

0.15 mM (20-25°C)

CMC

0.15 mM (20-25°C)

CMC

1.6 mM

General description

A water-soluble nonionic detergent. Studies on rhodopsin have shown that alkyl glycosides with longer alkyl chains are better at preserving the protein′s properties. In addition, dodecyl maltoside′s longer hydrophilic group confers higher solubility in water. This is in contrast to undecyl and dodecyl glucosides, which have low solubility in water. Due to its low CMC, dodecyl maltoside is not easily removed by dialysis. The half time for dialysis is 20 h. This detergent is milder than nonyl glucoside. Of several glycosides tested, dodecyl maltoside was found to be the most useful for the preparation of active cytochrome oxidase from Neurospora. In octyl glucoside, cytochrome oxidase dissociated into its subunits and became inactive. Similarly, beef heart oxidase when equilibrated in octyl glucoside formed a mixture of polymer, dimer, and lower molecular weight forms and underwent denaturation. In contrast, the enzyme, when equilibrated in dodecyl maltoside, was found to exist as a uniform species of 30 kDa, which is consistent with an active dimeric form. Dodecyl maltoside has a critical micelle concentration (CMC) of 100-600 µM and a micellar weight of 70,000. Aggregation number: 98.
Absorbance (10%, H2O, 260 nm): <1.0.
Non-ionic detergent similar to n-octyl-β-D-glucopyranoside; however, increased alkyl chain length has been shown to increase thermal stability of lipid-free rhodopsin in solution. Useful in membrane-protein solubilization studies. Aggregation number: 98.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, refrigerate (4°C).

Stock solutions are stable for up to 3 months at 4°C.

Other Notes

Witzmann, F., et al. 1991. Electrophoresis12, 687.
Bass, W.T., and Bricker, T.M. 1988. Anal. Biochem.171, 330.
Rosevear, P., et al. 1980. Biochemistry19, 4108.
Grip, W.J., and Bovee-Geurts, P.H.M. 1979. Chem. Phys. Lipids23, 321.
Stubbs, G.W., et al. 1976. Biochim. Biophys. Acta425, 46.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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