11162306001
Roche
ATP-γ-S
=90% (HPLC), solution, pkg of 200 μL (20 μmol)
Synonym(s):
adenosine-5′-o-(3-thio-triphosphate)
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About This Item
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Quality Level
description
C10H16N5O12P3SLi (Formula)
Lithium salt
assay
90% (HPLC)
form
solution
mol wt
523.2
packaging
pkg of 200 μL (20 μmol)
manufacturer/tradename
Roche
λmax
260 nm at 100 mmol/L
shipped in
dry ice
storage temp.
−20°C
General description
Adenosine 5′-O-(3-thiotriphosphate), lithium salt, solution.
Application
ATP-γ-S has been used:
- to treat THP-1 macrophage cell lines for testing if endoplasmic reticulum (ER) stress causes the production of interleukin (IL)-1β
- in amide hydrogen exchange (HX) experiments coupled to mass spectrometry and study the cyclomarin A (CymA)-induced structural changes in NMtb-ClpC
- as a supplement in CMG-binding buffer for gel-based DNA unwinding assays
Biochem/physiol Actions
Adenosine 5′-O-(3-thiotriphosphate) (ATP-γ-S) is a substrate and inhibitor of ATP-dependent enzyme systems. It is hydrolyzed very slowly by phosphatases and most ATPases. Once thiophosphorylated, proteins are resistant to protein phosphatases. ATP-γ-S serves as a damage-associated molecular pattern molecule (DAMP) and NLR family pyrin domain containing 3 (NLRP3) inflammasome activator. ATP-γ-S may serve as a substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eukaryotic initiation factor-4A (eIF4A).
Quality
Contaminants: ≤10% ADP (HPLC)
Other Notes
For life science research only. Not for use in diagnostic procedures.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
No data available
flash_point_c
No data available
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