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07969

Sigma-Aldrich

O-(2-Aminoethyl)polyethylene glycol 3,000

Mp 3,000

Synonym(s):

Aminopolyethylene glycol

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About This Item

Linear Formula:
NH2(CH2CH2O)nH
CAS Number:
32130-27-1
MDL number:
MFCD00286223
UNSPSC Code:
12162002
PubChem Substance ID:
24846131
NACRES:
NA.22

mol wt

Mp 3,000

Quality Level

100

reaction suitability

reagent type: cross-linking reagent

Ω-end

hydroxyl

α-end

amine

SMILES string

[H]OCCN

General description

O-(2-Aminoethyl)polyethylene glycol is a heterobifunctional polyethylene glycol (hydroxyl-PEG-amine) useful in conjugation and crosslinking reactions.

Application

O-(2-Aminoethyl)polyethylene glycol has been used to synthesize PEG-poly(D,L-lactide-co-glycolide) (PEG-PLGA) conjugate for use in the synthesis of PLGA-based nanoparticles.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6970
BCBW1386
BCBW0934
BCBV4499
BCBV5012

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Molly A Sowers et al.
Nature communications, 5, 5460-5460 (2014-11-19)
Stimuli-responsive multimodality imaging agents have broad potential in medical diagnostics. Herein, we report the development of a new class of branched-bottlebrush polymer dual-modality organic radical contrast agents--ORCAFluors--for combined magnetic resonance and near-infrared fluorescence imaging in vivo. These nitroxide radical-based nanostructures
Alan O Burts et al.
Photochemistry and photobiology, 90(2), 380-385 (2013-10-15)
New strategies for the synthesis of multifunctional particles that respond to external stimuli and release biologically relevant agents will enable the discovery of new formulations for drug delivery. In this article, we combine two powerful methods: brush-first ring-opening metathesis polymerization
Jeremiah A Johnson et al.
Journal of the American Chemical Society, 133(3), 559-566 (2010-12-15)
The combination of highly efficient polymerizations with modular "click" coupling reactions has enabled the synthesis of a wide variety of novel nanoscopic structures. Here we demonstrate the facile synthesis of a new class of clickable, branched nanostructures, polyethylene glycol (PEG)-branch-azide
Alan O Burts et al.
Macromolecular rapid communications, 35(2), 168-173 (2013-11-23)
This report describes the synthesis of miktoarm brush-arm star polymers (BASPs) from branched and linear norbornene-terminated macromonomers (MMs) via the brush-first ring-opening metathesis polymerization (ROMP) method. First, a polystyrene (PS)-branch-poly(lactic acid) (PLA) MM is synthesized via a combination of atom
Folic acid-decorated and PEGylated PLGA nanoparticles for improving the antitumour activity of 5-fluorouracil.
El-Hammadi
International Journal of Pharmaceutics, 516(1-2), 61-70 (2017)
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Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

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