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Poly(ethylene glycol) diamine

average Mn 2,000

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Synonym(s):
Poly(ethylene glycol) bis(amine), O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)
Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
MDL number:
NACRES:
NA.23

form

powder

mol wt

Mw/Mn ≤1.4
average Mn 2,000

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

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1 of 4

This Item
P9906752452752460
mol wt

Mw/Mn ≤1.4, average Mn 2,000

mol wt

average Mn 3400

mol wt

average Mn 3,000

mol wt

average Mn 10,000

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Ω-end

amine

Ω-end

amine

Ω-end

-

Ω-end

amine

α-end

amine

α-end

amine

α-end

-

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

polymer architecture

shape: linear
functionality: homobifunctional

General description

Poly(ethylene glycol) diamine (PEGD) is a non-toxic biopolymer which has properties such as biocompatibility and biodegradability. It can be reacted with crosslinking agents to form a three dimensional mesh that can be used in drug delivery systems. It can also be used as a non-ionic surfactant for a variety of biological applications.

Application

PEGD can be used as a crosslinked hydrogel and as a substrate in tissue engineering and biomedical applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Biodegradable poly (ethylene glycol) hydrogels crosslinked with genipin for tissue engineering applications
Moffat KL and Marra KG
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 71(1), 181-187 (2004)
Thermal and kinetic evaluation of biodegradable thermo-sensitive gelatin/poly (ethylene glycol) diamine crosslinked citric acid hydrogels for controlled release of tramadol
Rocha-Garcia D, et al.
European Polymer Journal, 89, 42-56 (2017)
Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering
Elbert DL and Hubbell JA
Biomacromolecules, 2(2), 430-441 (2001)
Rigidity of two-component hydrogels prepared from alginate and poly (ethylene glycol)- diamines
Eiselt P, et al.
Macromolecules, 32(17), 5561-5566 (1999)
Glass surfaces grafted with high-density poly (ethylene glycol) as substrates for DNA oligonucleotide microarrays
Schlapak R, et al.
Langmuir, 22(1), 277-285 (2006)

Articles

Highlighting new synthetic modifications of PEG to improve the mechanical properties and degradation of resulting hydrogels in tissue engineering applications.

The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.

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