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Sigma-Aldrich

D-(+)-Galactose

meets analytical specification of Ph. Eur., BP

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Synonym(s):
Galactose
Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
59-23-4
Molecular Weight:
180.16
Beilstein/REAXYS Number:
1724619
EC Number:
200-416-4
MDL number:
MFCD00151230
UNSPSC Code:
12352201
PubChem Substance ID:
57647466
NACRES:
NA.21

form

powder

Quality Level

200

quality

meets analytical specification of Ph. Eur., BP

technique(s)

IR spectroscopy: suitable

impurities

acid. or alk. react. impurities, in accordance
 microbiological impurity, in accordance
 residual solvents, in accordance
≤1.0% water (Karl Fischer)

color

white

useful pH range

5.0-7.0 (25 °C, 180 g/L)

mp

168-170 °C (lit.)

solubility

H2O: soluble 180 g/L at 20 °C

suitability

in accordance for appearance of solution
in accordance for identity (IR)

application(s)

pharmaceutical (small molecule)

SMILES string

OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O

InChI

1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6-/m0/s1

InChI key

GZCGUPFRVQAUEE-KCDKBNATSA-N

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Application

D-(+)-Galactose was used for examining the specificity of staining with SBA-FITC during labeling of cells for fluorescence-activated cell sorting (FACS). It was used for selecting the transformed strains of S. cerevisiae.

Biochem/physiol Actions

Galactose is a monosaccharide sugar and is the natural antigen present on the blood cells. It induces memory loss, neurodegeneration as well as oxidative damage in mice due to systemic exposure.
Galactose is a simple monosaccharide that serves as an energy source and as an essential component of glycolipids and glycoproteins. Galactose contributes to energy metabolism via its conversion to glucose by the enzymes that constitute the Leloir pathway. Defects in the genes encoding these proteins lead to the metabolic disorder galactosemia.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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P J Simmons et al.
Blood, 78(11), 2848-2853 (1991-12-01)
Normal bone marrow cells were isolated by fluorescence-activated cell sorting (FACS) on the basis of CD34 antigen expression and then assayed in vitro for colonies of fibroblastic cells (fibroblast colony-forming units [CFU-F]). Greater than 95% of detectable CFU-F were recovered
Elizabeth M Prescott et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(13), 8796-8801 (2002-06-22)
Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination
Xu Cui et al.
Journal of neuroscience research, 84(3), 647-654 (2006-05-20)
Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model. The underlying mechanism is yet unclear. To investigate the mechanisms of neurodegeneration in this model, we studied
Michelle P Christie et al.
PloS one, 9(4), e95024-e95024 (2014-04-17)
Glycosylation of biopharmaceuticals can mediate cell specific delivery by targeting carbohydrate receptors. Additionally, glycosylation can improve the physico-chemical (drug-like) properties of peptide based drug candidates. The main purpose of this study was to examine if glycosylation of the peptide enkephalin
Lu Han et al.
Biomaterials, 44, 111-121 (2015-01-27)
Multifunctional nanocomplexes (NCs) consisting of urocanic acid-modified galactosylated trimethyl chitosan (UA-GT) conjugates as polymeric vectors, poly(allylamine hydrochloride)-citraconic anhydride (PAH-Cit) as charge-reversible crosslinkers, and vascular endothelial growth factor (VEGF) siRNA as therapeutic genes, were rationally designed to simultaneously overcome the extracellular
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