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Supelco

Tulobuterol hydrochloride

VETRANAL®, analytical standard

Synonym(s):

2-tert-Butylamino-1-(2-chlorophenyl)ethanol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H18ClNO · HCl
CAS Number:
56776-01-3
Molecular Weight:
264.19
MDL number:
MFCD00214398
UNSPSC Code:
41116107
PubChem Substance ID:
329757956
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

assay

≥98.0% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Storage temp.

2-8°C

SMILES string

Cl.CC(C)(C)NCC(O)c1ccccc1Cl

InChI

1S/C12H18ClNO.ClH/c1-12(2,3)14-8-11(15)9-6-4-5-7-10(9)13;/h4-7,11,14-15H,8H2,1-3H3;1H

InChI key

RSLNRVYIRDVHLY-UHFFFAOYSA-N

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General description

Standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706019, T706030, T706020
Tulobuterol hydrochloride is a sympathomimetic amine, possessing bronchodilator activity.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tulobuterol hydrochloride may be used as a reference standard in determining the concentration of tulobuterol hydrochloride present in bovine liver homogenates and urine samples using gas chromatography coupled with tandem mass spectrometry (GC-MS-MS).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK9925
BCCH6222
BCCD9390
BCCC1945
BCBX5290

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Akinori Nakamura et al.
Chemical & pharmaceutical bulletin, 60(3), 300-305 (2012-03-03)
We proposed an in vitro/in vivo/in silico method for evaluating the clinical performance of matrix type transdermal therapeutic systems (TTSs). This method is based on the following four approaches: (1) drug release experiment, (2) in vitro penetration experiment using excised
T Sakamoto et al.
Die Pharmazie, 64(6), 361-365 (2009-07-22)
Applicability of a Terahertz Pulsed Spectroscopy (TPS) and a Terahertz Pulsed Imaging (TPI) for detection of tulobuterol (TBR) crystals in transdermal patches was investigated. Because TBR has high permeability in dermis, crystalline TBR in patch matrices contributes to controlling the
Gen Tamura et al.
Allergology international : official journal of the Japanese Society of Allergology, 61(2), 219-229 (2012-01-25)
Tulobuterol patch (HokunalinTM Tape), which contains a β(2)-adrenergic agonist, is the first bronchodilator to be available as a transdermal patch. This drug delivery system ensures that the time at which the peak drug concentration in the blood is reached coincides
Determination of β2-receptor agonists in bovine urine and liver by gas chromatography?tandem mass spectrometry
Leyssens L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 564(2), 515-527 (1991)
Masashi Kanehara et al.
Pulmonary pharmacology & therapeutics, 21(6), 874-878 (2008-11-06)
The airway inflammation of chronic obstructive pulmonary disease (COPD) demonstrates a poor response to the anti-inflammatory actions of corticosteroids. However, long-acting beta(2)-agonists and low-dose theophylline are reported to have a possible anti-inflammatory effect in COPD. The aim of this study
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