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673277

Sigma-Aldrich

2-Methyltetrahydrofuran

greener alternative

BioRenewable, anhydrous, ≥99%, Inhibitor-free

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Synonym(s):
2-MeTHF, Tetrahydro-2-methylfuran, Tetrahydrosilvan
Empirical Formula (Hill Notation):
C5H10O
CAS Number:
Molecular Weight:
86.13
Beilstein:
102448
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

anhydrous

Quality Level

Assay

≥99%

form

liquid

expl. lim.

0.34-6.3 % (lit.)

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

impurities

≤0.002% water
≤0.005% water (100 mL pkg)

evapn. residue

≤0.0003%

refractive index

n20/D 1.406 (lit.)

bp

78-80 °C (lit.)

mp

-136 °C (lit.)

density

0.86 g/mL at 25 °C (lit.)

greener alternative category

SMILES string

CC1CCCO1

InChI

1S/C5H10O/c1-5-3-2-4-6-5/h5H,2-4H2,1H3

InChI key

JWUJQDFVADABEY-UHFFFAOYSA-N

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This Item
155810854888.45103
2-Methyltetrahydrofuran analytical standard

Supelco

85488

2-Methyltetrahydrofuran

assay

≥99%

assay

≥99.5%

assay

≥99.5% (GC)

assay

≥98% (GC)

form

liquid

form

liquid

form

-

form

liquid

expl. lim.

0.34-6.3 % (lit.)

expl. lim.

0.34-6.3 %

expl. lim.

-

expl. lim.

1.2-5.7 % (v/v)

impurities

≤0.002% water, ≤0.005% water (100 mL pkg)

impurities

≤1.0% water (coulometr.), ≤100 ppm peroxide (as H2O2)

impurities

-

impurities

-

refractive index

n20/D 1.406 (lit.)

refractive index

n20/D 1.406 (lit.)

refractive index

n20/D 1.406 (lit.)

refractive index

n20/D 1.406 (lit.)

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with "Safer Solvents and Auxiliaries" and "Use of Renewable Feedstocks". Click here for more information.
2-Methyltetrahydrofuran (2-MTHF), a 2-methyl substituted tetrahydrofuran, is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide.

Application

2-Methyltetrahydrofuran may be used as a solvent for phosphatidylserine synthesis.
It may be used as an alternative solvent to:
  • Dimethyl sulfoxide (DMSO) or methyl tert-butyl ether (MTBE) in the C-C bond forming reactions catalyzed by lyase enzyme.
  • Tetrahydrofuran (THF) in the reaction between Grignard reagents and carbonyl compounds.
  • Methylene chloride in some biphasic reactions.
Green Alternatives to DCM and THF from Renewable Resources

Organic Solar Cells

2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry

Features and Benefits

Greener alternative for THF, DCM, DMSO, and MTBE

related product

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

14.0 °F - closed cup

Flash Point(C)

-10.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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