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77253

Supelco

Heptafluorobutyric anhydride

for GC derivatization, LiChropur, ≥99.0%

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Synonym(s):
HFAA, HFBA, Perfluorobutyric anhydride
Linear Formula:
(CF3CF2CF2CO)2O
CAS Number:
Molecular Weight:
410.06
Beilstein:
856036
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization

Quality Level

Assay

≥99.0% (GC)
≥99.0%

form

liquid

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.287 (lit.)

bp

108-110 °C (lit.)

mp

−43 °C (lit.)

density

1.674 g/mL at 20 °C (lit.)
1.674 g/mL at 20 °C

SMILES string

FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22

InChI key

UFFSXJKVKBQEHC-UHFFFAOYSA-N

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This Item
16419433214H1006
Heptafluorobutyric anhydride for GC derivatization, LiChropur™, ≥99.0%

Supelco

77253

Heptafluorobutyric anhydride

Acetic anhydride puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99% (GC)

Sigma-Aldrich

33214

Acetic anhydride

form

liquid

form

liquid

form

-

form

liquid

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

reaction suitability

-

reaction suitability

-

reaction suitability

-

refractive index

n20/D 1.287 (lit.)

refractive index

n20/D 1.3 (lit.)

refractive index

n20/D 1.390 (lit.)

refractive index

n20/D 1.287 (lit.)

bp

108-110 °C (lit.)

bp

120 °C/755 mmHg (lit.)

bp

138-140 °C (lit.)

bp

108-110 °C (lit.)

mp

−43 °C (lit.)

mp

-

mp

−73 °C (lit.)

mp

−43 °C (lit.)

General description

Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.

Application

Learn more in the Product Information

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Analysis Note

Suitable for derivatization of aldosterone, digoxin, digitoxin and metabolites, estradiol, postaglandins F and F2α, 3-oxo-Δ4-steroids, steroids and testosterone.

Other Notes

HFAA acylates amines, amino acids and other compounds. HFBA derivatives are highly volatile: used in GC separation
Reagent for 3-enol heptafluorobutyrate, heptafluorobutyrate, heptafluorobutyryl, 17-heptafluorobutyryl and 17-heptafluorobutyrate.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Methods for ultra trace detection of endocrine disruptive chemicals (EDCs) are needed because of their low levels of impact. Twenty-one EDCs were selected, including 17beta-estradiol, 17alpha-ethinylestradiol, 17beta-testosterone and bisphenol A. Derivatisation with eight different fluorine containing compounds was examined. All
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A convenient and sensitive method for the quantitative determination of poly(ethylene glycol) 400 in plasma and urine with capillary gas chromatography-mass spectrometry has been developed. The sample preparation involves solid-phase extraction with subsequent derivatization with heptafluorobutyric anhydride, which proved to
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The use of mushrooms containing the hallucinogenic substance psilocybin for intentional intoxication is relatively common. Occasionally, this results in adverse reactions with typical tachycardia that is not evidently caused by psilocybin. This study demonstrates the presence of phenylethylamine in the

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