902160

Phosphorus pentoxide

anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, 99%

• Synonym(s): Phosphoric anhydride, Phosphorus(V) oxide
• Linear Formula: P₂O₅
• CAS Number: 1314-56-3
• Molecular Weight: 141.94
• UNSPSC Code: 12352303
• PubChem Substance ID: 24852847
• NACRES: NA.21

Properties

• grade: anhydrous
• vapor density: 4.9 (vs air)
• vapor pressure: 1 mmHg ( 384 °C); 10 mmHg ( 238 °C)
• product line: ReagentPlus^®; Redi-Dri^™
• assay: 99%
• form: powder
• quality: free-flowing
• pH: 1.5 (20 °C, 10 g/L)
• mp: 340 °C (lit.)
• density: 2.3 g/mL at 25 °C (lit.)
• cation traces: As: ≤100 mg/kg; Fe: ≤100 mg/kg; heavy metals (as Pb): ≤0.02%
• SMILES string: O=P12OP3(=O)OP(=O)(O1)OP(=O)(O2)O3
• InChI: 1S/O10P4/c1-11-5-12(2)8-13(3,6-11)10-14(4,7-11)9-12
• InChI key: YWEUIGNSBFLMFL-UHFFFAOYSA-N

Description

General description

Phosphorus pentoxide is a deliquescent compound prepared by reacting phosphorus with air. It is a commonly used as dehydrating and condensing agent in organic synthesis.

Application

Dehydrating agent used for halogenation with tetrabutylammonium halides.

Process for Producing Halogenated Heteroaryl Compounds

Phosphorus pentachloride has been used for the vaccum distillation of 1-methyl-2-pyrrolidinone (NMP), which was employed as mobile phase in a chromatographic analysis.

It may be used as one of the reaction components in the synthesis of dichlorine heptoxide (Cl₂O₇) and transition-metal phosphides (Ni₂P, Co₂P and MoP). P₂O₅ supported on alumina can be used for the solvent-free and microwave-assisted preparation of 1, 5-benzodiazepine analogs. P₂O₅/KX (X = Br, I) reagent system may be used for the transformation of alcohols into the corresponding alkyl iodides and bromides.

Phosphorus pentoxide/methanesulfonic acid (PPMA) may be used as a condensing agent and solvent for the synthesis of:

• High molecular weight poly(benzoxazole)s via direct polycondensation of aromatic dicarboxylic acids containing phenyl ether structure with 3,3′-dihydroxybenzidine dihydrochloride.
• Aromatic poly(phenylene ether ether ketone)s via direct self-polycondensation of 4-(4′-phenoxyphenoxy)benzoic acids.
• 1,3-1H-dibenzimidazole-benzene by the reaction of isophthalic acid with 1,2-diaminobenzene.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1A
• supp_hazards: EUH014
• Storage Class: 8B - Non-combustible corrosive hazardous materials
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable