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B5775

Supelco

Bendroflumethiazide

analytical standard

Synonym(s):

3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C15H14F3N3O4S2
CAS Number:
73-48-3
Molecular Weight:
421.41
EC Number:
200-800-1
MDL number:
MFCD00078963
UNSPSC Code:
41116107
PubChem Substance ID:
329773267
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F

InChI

1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)

InChI key

HDWIHXWEUNVBIY-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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General description

Bendroflumethiazide belongs to the class of thiazide diuretics, widely used in enhancing diuresis. It is also used as an effective antihypertensive agent and in the treatment of edema caused by cardiac/renal failure and myocardial infarction. Its mode of action involves increasing the urine flow and the net renal excretion of both sodium and water.

Application

Bendroflumethiazide may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000293837
079F1025V
079F1025
079F1025

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The
Current Cardiovascular Drugs, 9(4), 1069-1076 (2005)
Isla S Mackenzie et al.
Hypertension (Dallas, Tex. : 1979), 54(2), 409-413 (2009-06-03)
Isolated systolic hypertension is an important risk factor for cardiovascular disease and results primarily from elastic artery stiffening. Although various drug therapies are used to lower peripheral blood pressure (BP) in patients with isolated systolic hypertension, the effects of the
Analysis of diuretic doping agents by HPLC screening and GC?MSD confirmation
Tsai Y-F, et al.
Journal of Pharmaceutical and Biomedical Analysis, 9(10-12), 1069-1076 (1991)
D Tricarico et al.
British journal of pharmacology, 154(1), 183-190 (2008-03-18)
Acetazolamide and dichlorphenamide are carbonic anhydrase (CA) inhibitors effective in the clinical condition of hypokalemic periodic paralysis (hypoPP). Whether these drugs prevent vacuolar myopathy, which is a pathogenic factor in hypoPP, is unknown. The effects of these drugs on the
Hari K Parthasarathy et al.
Journal of hypertension, 28(1), 170-177 (2009-12-17)
We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750
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Chromatograms

application for HPLC

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