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E6133

Sigma-Aldrich

Ethanolamine hydrochloride

≥99.0%

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Synonym(s):
mea hydrochloride, monoethanolamine hydrochloride, 2-Aminoethanol hydrochloride
Linear Formula:
H2NCH2CH2OH · HCl
CAS Number:
Molecular Weight:
97.54
Beilstein/REAXYS Number:
3542892
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

≥99.0%

form

powder or crystals

storage condition

dry at room temperature

technique(s)

HPLC: suitable

color

white

pH

9—10

pKa (25 °C)

9.5

mp

82-84 °C (lit.)

solubility

water: 0.33 g/mL, clear, colorless to very faintly yellow

density

1.07 g/cm3 at 20—25 °C
1.12 g/cm3 at 20—25 °C

suitability

suitable for chromatography

application(s)

general analytical
life science and biopharma
pharmaceutical

SMILES string

NCCO.[H]Cl

InChI

1S/C2H7NO.ClH/c3-1-2-4;/h4H,1-3H2;1H

InChI key

PMUNIMVZCACZBB-UHFFFAOYSA-N

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General description

Ethanolamine hydrochloride, a versatile compound in biochemistry and molecular biology, plays a pivotal role in diverse research areas. Primarily, it functions as a buffering agent, ensuring a stable pH environment crucial for enzymatic reactions, protein solubilization, and other biological processes. Its significance extends to membrane protein studies, aiding in the extraction of these proteins from cell membranes. It also finds utility in cell culture and as a reagent for biological sample preparation, simplifying nucleic acid and protein isolation, as well as facilitating the detection of proteins by western blotting and immunohistochemistry. This compound′s wide-ranging applications make it indispensable in biochemical research, contributing to various experimental procedures and advancing our understanding in fields such as molecular biology, immunology, and cellular biology.

Application

Ethanolamine hydrochloride has been used:
  • in overnight incubation of the tips to attach primary amine groups at the tip surface
  • in the preparation of DMEM (dulbecco′s modified eagle′s medium)/F-12 media to culture human epidermal growth factor receptor 2 (HER2) cells derived from MMTV-HER2 transgenic mouse mammary tumors
  • to administer the cultures to study its effect on the endogenous phosphatidyl ethanolamine pool and autophagy process
  • in a study as a reagent to study molecular interactions and adhesion forces in biological systems using Atomic Force Microscopy
  • to prepare the reagent for surface-enhanced laser desorption ionization analysis, aimed at studying the role of Interleukins

Biochem/physiol Actions

Ethanolamine hydrochloride is utilized as a carbon and nitrogen source by bacteria that differs phylogenetically. It exists as phosphotidylethanolamine in the bacterial and mammalian cell membrane. Ethanolamine-ammonia lyase is responsible for the degradation of ethanolamine into acetaldehyde and ammonia. Ethanolamine is known to positively support lipid accumulation in photosynthetic organism model.

Features and Benefits

  • Suitable for Immunology, Cellular Biology and Biochemical Research
  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
  • Effective Buffering Agent with a pKa of 9.5 (25 °C)

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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