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Sigma-Aldrich

Ethylenediaminetetraacetic acid dipotassium salt dihydrate

≥98%

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Synonym(s):
(Ethylenedinitrilo)tetraacetic acid dipotassium salt, Dipotassium ethylenediaminetetraacetate dihydrate, EDTA dipotassium salt, Edathamil, Potassium ethylenediaminetetraacetate dibasic
Linear Formula:
HOOCCH2(KOOCCH2)NCH2CH2N(CH2COOK)CH2COOH · 2H2O
CAS Number:
Molecular Weight:
404.45
EC Number:
NACRES:
NA.77

biological source

synthetic

Quality Level

assay

≥98%

form

powder

reaction suitability

reagent type: chelator

pH

4.0-5.0 (25 °C, 40.4 g/L)

mp

255-280 °C (dec.) (lit.)

solubility

3 M KOH: 160 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

room temp

SMILES string

O.O.O.O.[K+].[K+].[K+].[K+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2K.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

JFROQFOCFOKDKU-UHFFFAOYSA-L

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This Item
036608.19040E0270
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

solubility

3 M KOH: 160 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

-

solubility

-

solubility

3 M KOH: 160 mg/mL, clear, colorless

pH

4.0-5.0 (25 °C, 40.4 g/L)

pH

4-5 (25 °C, 50 mg/mL in H2O)

pH

4-5 (20 °C, 50 g/L in H2O)

pH

8-9 (20 °C, 50 g/L)

mp

255-280 °C (dec.) (lit.)

mp

255-280 °C (dec.) (lit.)

mp

272 °C

mp

182 °C (dec.) (lit.)

form

powder

form

-

form

solid

form

powder

Application

Ethylenediaminetetraacetic acid dipotassium salt dehydrate has been used as a component:
  • of EDTA–glycerol solution (EDTA-G) for decalcification
  • of buffer for monoamine and pterine analysis
  • of T-cell resuspension buffer

Used to eliminate inhibition of enzyme catalyzed reactions due to traces of heavy metals

Biochem/physiol Actions

Ethylenediaminetetraacetic acid (EDTA) is an anticoagulant, majorly used in preventing clotting of blood. EDTA may trigger aggregation of platelets resulting in pseudothrombocytopenia. EDTA-tetracycline therapy decreases coronary artery calcium levels in atherosclerosis. Calcium disodium EDTA administration is effective in slowing down the progression of chronic kidney disease. It also enhances the antimicrobial functionality of lysozyme and improves shelf life of cheese.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Inhalation

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Cytochrome c oxidase activity is a metabolic checkpoint that regulates cell fate decisions during T cell activation and differentiation
Tarasenko TN, et al.
Cell Metabolism, 25(6), 1254-1268 (2017)
A novel decalcification method for adult rodent bone for histological analysis of peripheral-central nervous system connections
Begum F, et al.
Journal of Neuroscience Methods, 187(1), 59-66 (2010)
Whole body insulin responsiveness is higher in beef steers selected for increased muscling
McGilchrist P, et al.
Animal : An International Journal of Animal Bioscience, 5(10), 1579-1586 (2011)
Comparison of the efficacy of ethylenediaminetetraacetic acid and tetracycline hydrochloride as root conditioning agents: An in vitro study
Nanda T, et al.
Journal of the International Clinical Dental Research Organization, 4(1), 2-2 (2012)
Lysozyme/EDTA disodium salt and modified-atmosphere packaging to prolong the shelf life of burrata cheese
Conte A, et al.
Journal of Dairy Science, 94(11), 5289-5297 (2011)

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