I0775010
Isosorbide mononitrate
European Pharmacopoeia (EP) Reference Standard
Synonym(s):
1,4:3,6-Dianhydro-D-glucitol 5-nitrate
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About This Item
Empirical Formula (Hill Notation):
C6H9NO6
CAS Number:
Molecular Weight:
191.14
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24
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grade
pharmaceutical primary standard
API family
isosorbide
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
InChI
1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1
InChI key
YWXYYJSYQOXTPL-SLPGGIOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Isosorbide mononitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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Product No.
Description
Pricing
signalword
Danger
hcodes
Hazard Classifications
Flam. Sol. 1
Storage Class
4.1A - Other explosive hazardous materials
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Priyadarshani Galappatthy et al.
Heart (British Cardiac Society), 104(17), 1424-1431 (2018-02-18)
Ischaemic heart disease is the leading cause of in-hospital mortality in Sri Lanka. Acute Coronary Syndrome Sri Lanka Audit Project (ACSSLAP) is the first national clinical-audit project that evaluated patient characteristics, clinical outcomes and care provided by state-sector hospitals. ACSSLAP
Yuan Li et al.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 46(2), 145-152 (2019-05-06)
Hyperbaric oxygen (HBO2) therapy improves myocardial function and reduces clinical restenosis in coronary arteries. This study aims to evaluate whether the HBO2 therapy can improve vascular endothelial dysfunction in patients undergoing coronary stent implantation. The retrospective study included 115 patients
L L Gluud et al.
Alimentary pharmacology & therapeutics, 32(7), 859-871 (2010-09-16)
The evidence concerning the use of isosorbide-mononitrate (IsMn) for oesophageal varices is equivocal. To assess the effects of IsMn for patients with oesophageal varices and no previous bleeding (primary prevention) or previous variceal bleeding (secondary prevention). Systematic review with meta-analyses
Mark J Bolland et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 35(6), 1040-1047 (2020-05-07)
Organic nitrates have been reported to have significant effects on bone mineral density (BMD) and bone turnover in previous clinical trials. However, results are inconsistent and some trials with strikingly positive results have been retracted because of scientific misconduct. As
U W Abshagen
The American journal of cardiology, 70(17), 61G-66G (1992-11-27)
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable. The half-life is approximately 5 hours, the volume of distribution is 0.62
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