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Key Documents

M1650000

Methyl parahydroxybenzoate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Methyl 4-hydroxybenzoate, p-Hydroxybenzoic acid methyl ester, Methyl paraben, NIPAGIN

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About This Item

Linear Formula:
HOC6H4CO2CH3
CAS Number:
Molecular Weight:
152.15
Beilstein/REAXYS Number:
509801
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

parabens

manufacturer/tradename

EDQM

mp

125-128 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

COC(=O)c1ccc(O)cc1

InChI

1S/C8H8O3/c1-11-8(10)6-2-4-7(9)5-3-6/h2-5,9H,1H3

InChI key

LXCFILQKKLGQFO-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for use according to European Pharmacopoeia for the preparation of the below-given solutions:
  • Reference solutions (a) and (b) in the identification, testing for related substances, and assay of methyl parahydroxybenzoate and sodium methyl parahydroxybenzoate, according to the monographs 0409 and 1262
  • Reference solution (c) for the testing of related substances in nifuroxazide using liquid chromatography (2.2.29), according to the monograph 1999
  • Reference solution (b) in the identification of sodium ethyl parahydroxybenzoate using thin-layer chromatography (General text 2.2.27), according to the monograph 2134

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Environment

hcodes

Hazard Classifications

Aquatic Chronic 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

334.4 °F

flash_point_c

168 °C


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Sodium Ethyl Parahydroxybenzoate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3816-3817 (2017)
Sodium Methyl Parahydroxybenzoate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3830-3831 (2017)
Nifuroxazide
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3363-3364 (2017)
Methyl parahydroxybenzoate
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 6180-6181 (2022)
Gabriela Oliveira et al.
International journal of pharmaceutics, 435(1), 38-49 (2012-05-29)
Simple topical formulations which include volatile components, such as gels or sprays, are appealing from a cosmetic perspective. However, complex formulation effects may result from the use of volatile excipients in topical formulations, particularly when applied at clinically relevant doses

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