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PHR1010

Supelco

Propylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Propyl 4-hydroxybenzoate, 4-Hydroxybenzoic acid propyl ester, Propyl paraben
Linear Formula:
HOC6H4CO2CH2CH2CH3
CAS Number:
Molecular Weight:
180.20
Beilstein:
1103245
EC Number:
MDL number:
PubChem Substance ID:
E Number:
E216
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. P3650000
traceable to USP 1577008

API family

parabens

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

95-98 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCOC(=O)c1ccc(O)cc1

InChI

1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

InChI key

QELSKZZBTMNZEB-UHFFFAOYSA-N

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This Item
16897P36500001.07427
Propylparaben Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1010

Propylparaben

Propylparaben certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

16897

Propylparaben

Propyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard

P3650000

Propyl parahydroxybenzoate

Propyl 4-hydroxybenzoate EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

SAFC

1.07427

Propyl 4-hydroxybenzoate

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

-

technique(s)

API processing | cocrystal formation: suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

application(s)

environmental

application(s)

pharmaceutical (small molecule)

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

format

neat

format

neat

format

neat

format

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

15-25°C

Quality Level

300

Quality Level

300

Quality Level

-

Quality Level

500

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Propylparaben is the benzoate ester, widely used as a preservative in personal care products.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2080 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

356.0 °F

Flash Point(C)

180 °C


Certificates of Analysis (COA)

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Hye-Min Kang et al.
Chemosphere, 226, 388-394 (2019-04-05)
Parabens are used as a preservative substance in a wide range of man-made products causing deleterious effects on aquatic organisms and therefore, the concern of their effects to aquatic organisms has been increased. In this study, acute toxicity of methylparaben
José Manuel Pérez Martín et al.
Mutation research, 702(1), 86-91 (2010-08-05)
Propyl p-hydroxybenzoate, commonly referred to as propylparaben, is the most frequently used preservative to inhibit microbial growth and extend shelf life of a range of consumer products. The objective of this study was to provide further insight into the toxicological
Aeshna Amin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 75(2), 206-212 (2010-03-09)
p-Hydroxybenzoic acid esters (parabens) are commonly used antimicrobial preservatives in pharmaceutical formulations. Two microorganisms, isolated from non-sterile methyl paraben (MP) and propyl paraben (PP) solutions, were found to degrade the respective parabens. Identification by 16S rRNA partial gene sequencing revealed
Stephanie Marchese et al.
PloS one, 7(10), e45767-e45767 (2012-10-12)
Estrogens regulate the proliferation of normal and neoplastic breast epithelium. Although the intracellular mechanisms of estrogens in the breast are largely understood, little is known about how they induce changes in the structure of the mammary epithelium, which are characteristic
Yang Wang et al.
Analytica chimica acta, 673(2), 145-150 (2010-07-06)
A selective, sensitive, rapid and reliable method based on molecularly imprinted polymers (MIPs) with dual templates to determine total content of parabens in cosmetics was developed. With methylparaben (MP) and propylparaben (PP) as dual-templates, methacrylic acid (MAA) as a functional

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