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PHR1010

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Propylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Propyl 4-hydroxybenzoate, 4-Hydroxybenzoic acid propyl ester, Propyl paraben

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About This Item

Linear Formula:
HOC6H4CO2CH2CH2CH3
CAS Number:
Molecular Weight:
180.20
Beilstein/REAXYS Number:
1103245
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
E Number:
E216
NACRES:
NA.24

Pricing and availability is not currently available.

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. P3650000
traceable to USP 1577008

API family

parabens

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

95-98 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Propylparaben is the benzoate ester, widely used as a preservative in personal care products.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2080 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

hcodes

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

356.0 °F

flash_point_c

180 °C


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Certificates of Analysis (COA)

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Hye-Min Kang et al.
Chemosphere, 226, 388-394 (2019-04-05)
Parabens are used as a preservative substance in a wide range of man-made products causing deleterious effects on aquatic organisms and therefore, the concern of their effects to aquatic organisms has been increased. In this study, acute toxicity of methylparaben
O Herrero et al.
Mutation research, 743(1-2), 20-24 (2012-01-18)
Di(2-ethylhexyl)phthalate, triclosan and propylparaben are contaminants of emerging concern that have been subjected to extensive toxicological studies, but for which limited information is currently available concerning adverse effects on terrestrial plant systems. The Allium cepa test, which is considered one
Michelle P Dvores et al.
Langmuir : the ACS journal of surfaces and colloids, 28(17), 6978-6984 (2012-03-29)
This study presents a method for one-step formation of poly(ethylene oxide) nanofibers incorporating nanoparticles of a poorly water-soluble compound. Using the new method reported here, nanofiber-nanoparticle composites are fabricated in one step by electrospinning of an oil-in-water microemulsion, in which
José Manuel Pérez Martín et al.
Mutation research, 702(1), 86-91 (2010-08-05)
Propyl p-hydroxybenzoate, commonly referred to as propylparaben, is the most frequently used preservative to inhibit microbial growth and extend shelf life of a range of consumer products. The objective of this study was to provide further insight into the toxicological
Dennis G Maki et al.
Critical care medicine, 39(4), 613-620 (2011-01-05)
Catheter-related bloodstream infection is the greatest threat to the safety of patients on hemodialysis. Catheter lock solutions containing heparin have been linked to an increased risk of hemorrhage and thrombocytopenia. To ascertain the safety and efficacy for prevention of catheter-related

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