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P0270000

Papaverine hydrochloride

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
Empirical Formula (Hill Notation):
C20H21NO4 · HCl
CAS Number:
Molecular Weight:
375.85
Beilstein/REAXYS Number:
3921435
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

papaverine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl

InChI

1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChI key

UOTMYNBWXDUBNX-UHFFFAOYSA-N

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1 of 4

This Item
1496008PHR1182BP277
Papaverine hydrochloride European Pharmacopoeia (EP) Reference Standard

P0270000

Papaverine hydrochloride

Papaverine hydrochloride United States Pharmacopeia (USP) Reference Standard

1496008

Papaverine hydrochloride

Papaverine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1182

Papaverine hydrochloride

Papaverine hydrochloride British Pharmacopoeia (BP) Reference Standard

BP277

Papaverine hydrochloride

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

food and beverages
pharmaceutical (small molecule)

application(s)

pharmaceutical

API family

papaverine

API family

papaverine

API family

papaverine

API family

papaverine

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Papaverine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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I B Ivshina et al.
World journal of microbiology & biotechnology, 28(10), 2997-3006 (2012-07-19)
Drotaverine [1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline] hydrochloride, an antispasmodic drug derived from benzylisoquinoline was evaluated for its biodegradability using a bacterial strain Rhodococcus rhodochrous IEGM 608. The experiments were performed under aerobic conditions with rhodococci cultures able to degrade drotaverine. In the presence of
Brian Lima et al.
The Journal of thoracic and cardiovascular surgery, 143(4), 945-952 (2012-02-22)
An array of neuroprotective strategies has evolved to limit spinal cord injury during descending thoracic aneurysm and thoracoabdominal aortic aneurysm repair. This study prospectively assessed the neuroprotective impact of intrathecal papaverine added to other techniques in aortic aneurysm repairs. From
Naomi Osakabe et al.
Life sciences, 91(23-24), 1196-1200 (2012-09-18)
Numerous clinical studies have reported that ingestion of cocoa has a therapeutic effect on hypertension. However, there is only limited information on the mechanism of ingestion of cocoa on arterioles, vessels that have a major role in determining blood pressure.
Shaukat Nawaz Khan et al.
The Cochrane database of systematic reviews, 10, CD003635-CD003635 (2012-10-19)
During aortic aneurysm surgery, cross-clamping can lead to inadequate blood supply to the spinal cord resulting in neurological deficit. Cerebrospinal fluid drainage (CSFD) may increase the perfusion pressure to the spinal cord and hence reduce the risk of ischaemic spinal
Y Yazir et al.
International journal of impotence research, 24(5), 185-190 (2012-05-11)
Epidemiological evidence showed that chronic ethanol consumption is a major risk factor in the development of impotence. The present study investigated the effects of carbachol-, electrical field stimulation (EFS)-, sodium nitroprusside (SNP)- and papaverine-induced relaxant responses in the isolated corpus

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