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PHR1182

Supelco

Papaverine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
6,7-Dimethoxy-1-veratrylisoquinoline hydrochloride
Empirical Formula (Hill Notation):
C20H21NO4 · HCl
CAS Number:
Molecular Weight:
375.85
Beilstein/REAXYS Number:
3921435
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 277
traceable to Ph. Eur. P0270000
traceable to USP 1496008

API family

papaverine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

COC1=C(OC)C=C(C(CC2=CC(OC)=C(OC)C=C2)=NC=C3)C3=C1.Cl

InChI

1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChI key

UOTMYNBWXDUBNX-UHFFFAOYSA-N

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This Item
P0270000BP277PHL82620
Papaverine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1182

Papaverine hydrochloride

Papaverine hydrochloride European Pharmacopoeia (EP) Reference Standard

P0270000

Papaverine hydrochloride

Papaverine hydrochloride British Pharmacopoeia (BP) Reference Standard

BP277

Papaverine hydrochloride

Papaverine hydrochloride phyproof® Reference Substance

PHL82620

Papaverine hydrochloride

format

neat

format

neat

format

neat

format

-

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

primary reference standard

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

agency

traceable to BP 277

agency

-

agency

-

agency

-

General description

Papaverine hydrochloride is the hydrochloride salt of an opiate derivative called papaverine, a benzylisoquinoline compound. It has been found to relax smooth muscles of blood vessels and is used in the management of occlusivity and spasticity of pulmonary, coronary and peripheral arteries.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Papaverine hydrochloride is used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Smooth muscle relaxant and cerebral vasodilator; phosphodiesterase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9001 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations
Abdel-Ghani NT, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(2), 373-378 (2002)
The effect of intravenous papaverine hydrochloride on the cerebral circulation
Jayne H W, et al
The Journal of Clinical Investigation, 31(1), 111-114 (1952)
Simultaneous assay of ephedrine hydrochloride, theophylline, papaverine hydrochloride and hydroxyzine hydrochloride in tablets using RP-LC
Boberi B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 21(1), 15-22 (1999)
Simultaneous determination of dipyrone and papaverine in pharmaceutical formulation using PLS regression and UV spectrophotometry
do Nascimento AP, et al.
Analytical Letters, 40(5), 975-986 (2007)
Alaa El-Gindy
Farmaco (Societa chimica italiana : 1989), 60(9), 745-753 (2005-07-19)
Three methods are developed for the simultaneous determination of diprophylline (DP), phenobarbitone (PH) and papaverine hydrochloride (PP). The chromatographic method depends on a high performance liquid chromatographic (HPLC) separation on a reversed-phase C18 column with a mobile phase consisting of

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