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P45907

Sigma-Aldrich

Piperazine

ReagentPlus®, 99%

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Synonym(s):
1,4-Diazacyclohexane, Diethylenediamine
Empirical Formula (Hill Notation):
C4H10N2
CAS Number:
Molecular Weight:
86.14
Beilstein:
102555
EC Number:
MDL number:
eCl@ss:
39160301
PubChem Substance ID:
NACRES:
NA.21

vapor pressure

0.8 mmHg ( 20 °C)

Quality Level

product line

ReagentPlus®

Assay

99%

form

solid

expl. lim.

14 %

impurities

<1% water

pH

10.8-11.8 (100 g/L)

bp

145-146 °C (lit.)

mp

109-112 °C (lit.)

solubility

H2O: 0.9 g/L at 20 °C

SMILES string

C1CNCCN1

InChI

1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2

InChI key

GLUUGHFHXGJENI-UHFFFAOYSA-N

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1 of 4

This Item
806211541601SMB00097
Piperazine ReagentPlus&#174;, 99%

Sigma-Aldrich

P45907

Piperazine

-
Piperazine BioUltra, anhydrous, &#8805;99.0% (T)

Sigma-Aldrich

80621

Piperazine

Premium Grade
Piperazine United States Pharmacopeia (USP) Reference Standard

USP

1541601

Piperazine

-
Piperanine &#8805;95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00097

Piperanine

-
assay

99%

assay

≥99.0% (T)

assay

-

assay

≥95% (LC/MS-ELSD)

form

solid

form

solid

form

-

form

solid

expl. lim.

14 %

expl. lim.

14 %

expl. lim.

14 %

expl. lim.

-

impurities

<1% water

impurities

insoluble matter, passes filter test, ≤1% water

impurities

-

impurities

-

pH

10.8-11.8 (100 g/L)

pH

11.0-12.5 (25 °C, 0.1 M in H2O)

pH

-

pH

-

General description

Piperazine (PZ) is an amine solvent. The ability of aqueous PZ to absorb carbon dioxide (CO2) has been assessed. It is reported to cause paralysis in Ascaris worms. The analysis of the crystal structure of PZ at 150K shows the presence of layered structure with NH...N hydrogen-bonded chains.

Application

Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.
Piperazine may be used in the preparation of N-(hetero)arylpiperazines.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Eye Dam. 1 - Flam. Sol. 1 - Repr. 2 - Resp. Sens. 1B - Skin Corr. 1B - Skin Sens. 1B

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Carbon dioxide capture with concentrated, aqueous piperazine.
Freeman SA, et al.
International Journal of Greenhouse Gas Control, 4(2), 119-124 (2010)
Absorption of carbon dioxide into aqueous piperazine: reaction kinetics, mass transfer and solubility.
Bishnoi S and Rochelle GT.
Chemical Engineering Science, 55(22), 5531-5543 (2000)
Investigations on the action of piperazine on Ascaris lumbricoides.
Norton S and De Beer EJ.
The American Journal of Tropical Medicine and Hygiene, 6(5), 898-905 (1957)
Synthesis of N-arylpiperazines from aryl halides and piperazine under a palladium tri-tert-butylphosphine catalyst.
Nishiyama M, et al.
Tetrahedron Letters, 39(7), 617-620 (1998)
Andrew Parkin et al.
Acta crystallographica. Section B, Structural science, 60(Pt 2), 219-227 (2004-03-16)
The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so

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