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PHR1126

Supelco

Sulfamethoxazole

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide, N1-(5-Methylisoxazol-3-yl)sulfanilamide
Empirical Formula (Hill Notation):
C10H11N3O3S
CAS Number:
Molecular Weight:
253.28
Beilstein/REAXYS Number:
6732984
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 314
traceable to Ph. Eur. S2100000
traceable to USP 1631001

API family

sulfamethoxazole

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1

InChI

1S/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)

InChI key

JLKIGFTWXXRPMT-UHFFFAOYSA-N

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This Item
761771631001S2100000
Sulfamethoxazole Pharmaceutical Secondary Standard; Certified Reference Material

PHR1126

Sulfamethoxazole

Sulfamethoxazole certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

76177

Sulfamethoxazole

Sulfamethoxazole United States Pharmacopeia (USP) Reference Standard

1631001

Sulfamethoxazole

Sulfamethoxazole European Pharmacopoeia (EP) Reference Standard

S2100000

Sulfamethoxazole

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

-

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Sulfamethoxazole is one of the most effective sulfa drugs used for treating urinary infections in humans.

Application

Sulfamethoxazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by square-wave voltammetry, and visible/UV spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA6910 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardEnvironment

signalword

Warning

Hazard Classifications

Aquatic Chronic 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2


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Electroanalytical determination of sulfadiazine and sulfamethoxazole in pharmaceuticals using a boron-doped diamond electrode.
Souza CD, et al.
Sensors and Actuators B, Chemical, 135(1), 66-73 (2008)
Determination of sulfamethoxazole and trimethoprim in pharmaceuticals by visible and UV spectrophotometry.
Shamsa F and Amani L
Iranian Journal of Pharmaceutical Research : IJPR, 31-36 (2010)
Ming Xie et al.
Water research, 47(13), 4567-4575 (2013-06-15)
The impact of humic acid fouling on the membrane transport of two pharmaceutically active compounds (PhACs) - namely carbamazepine and sulfamethoxazole - in forward osmosis (FO) was investigated. Deposition of humic acid onto the membrane surface was promoted by the
Alexandra G Gonçalves et al.
Journal of hazardous materials, 239-240, 167-174 (2012-09-27)
Two carbon materials (multi-walled carbon nanotubes, MWCNTs, and activated carbon) were investigated as ozonation catalysts for the mineralization of the antibiotic sulphamethoxazole (SMX). MWCNTs presented a higher catalytic performance than activated carbons, which was justified by their differences in surface
Karl J Schreiber et al.
BMC plant biology, 12, 226-226 (2012-11-28)
The sulfanilamide family comprises a clinically important group of antimicrobial compounds which also display bioactivity in plants. While there is evidence that sulfanilamides inhibit folate biosynthesis in both bacteria and plants, the complete network of plant responses to these compounds

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