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Y0000412

Sulfamethoxazole impurity A

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
N4-Acetylsulfamethoxazole, N-Acetyl sulfamethoxazole, Acetyl-sulfamethoxazole, N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide, Sulfisomezole-N4-acetate
Empirical Formula (Hill Notation):
C12H13N3O4S
CAS Number:
Molecular Weight:
295.31
Beilstein/REAXYS Number:
285801
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

sulfamethoxazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=S(NC1=NOC(C)=C1)(C2=CC=C(NC(C)=O)C=C2)=O

InChI

1S/C12H13N3O4S/c1-8-7-12(14-19-8)15-20(17,18)11-5-3-10(4-6-11)13-9(2)16/h3-7H,1-2H3,(H,13,16)(H,14,15)

InChI key

GXPIUNZCALHVBA-UHFFFAOYSA-N

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1 of 4

This Item
Y0000413Y0000115S2100000
Sulfamethoxazole impurity A European Pharmacopoeia (EP) Reference Standard

Y0000412

Sulfamethoxazole impurity A

vibrant-m

Y0000413

Sulfamethoxazole impurity F

vibrant-m

Y0000115

Sotalol impurity B

Sulfamethoxazole European Pharmacopoeia (EP) Reference Standard

S2100000

Sulfamethoxazole

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

format

neat

format

neat

format

neat

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

API family

sulfamethoxazole

API family

sulfamethoxazole

API family

sotalol

API family

sulfamethoxazole

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sulfamethoxazole impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Xiang-yang Li et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 46(9), 1117-1122 (2011-11-30)
The paper is to report the pharmacokinetics of sulfamethoxazole in healthy Han volunteers living at plain (PH) and native Han and Tibetan healthy volunteers living at high altitude (HNH and HNT). After healthy volunteers were administrated orally cotrimoxazole tablets, plasma
Significance of apparent half-lives of a metabolite with a higher elimination rate than its parent drug.
T B Vree et al.
Drug intelligence & clinical pharmacy, 16(2), 126-131 (1982-02-01)
R Gochin et al.
Journal of chromatography, 223(1), 139-145 (1981-04-10)
The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetyl-sulphamethoxazole in serum and urine by high-performance liquid chromatography using sulphafurazole as internal standard is described. The separation was achieved on a reversed-phase column employing acetic acid-methanol as the mobile phase with spectrophotometric
T B Vree et al.
Journal of veterinary pharmacology and therapeutics, 6(1), 77-81 (1983-03-01)
Sulphamethoxazole and its metabolite, N4-acetylsulphamethoxazole, were shown to cross the placenta of a pregnant ewe. The plasma concentration of N4-acetylsulphamethoxazole increased in the foetus due to the limited elimination properties of the immature kidney. The amniotic fluid concentration of sulphamethoxazole
Acetylation of sulphamethoxazole by the snail Cepaea hortensis.
T B Vree et al.
Journal of veterinary pharmacology and therapeutics, 7(3), 239-241 (1984-09-01)

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