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PHR1280

Supelco

Xylitol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Xylite
Linear Formula:
HOCH2[CH(OH)]3CH2OH
CAS Number:
Molecular Weight:
152.15
Beilstein/REAXYS Number:
1720523
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. X0080000
traceable to USP 1720600

API family

xylitol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

94-97 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC[C@@H](O)[C@H](O)[C@@H](O)CO

InChI

1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+

InChI key

HEBKCHPVOIAQTA-SCDXWVJYSA-N

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1 of 4

This Item
X3375W5079301720600
vibrant-m

PHR1280

Xylitol

vibrant-m

X3375

Xylitol

vibrant-m

W507930

Xylitol

vibrant-m

1720600

Xylitol

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

flavors and fragrances

application(s)

pharmaceutical (small molecule)

format

neat

format

-

format

-

format

neat

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

-

grade

pharmaceutical primary standard

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Xylitol is a naturally occurring polyhydric sugar alcohol with high sweetening power and anticariogenic properties.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Xylitol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by capillary isotachophoresis.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4431 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Separation and determination of sorbitol and xylitol in multi-component pharmaceutical formulations by capillary isotachophoresis
Pospisilova M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 17(3), 387-392 (1998)
The effect of xylitol on dental caries and oral flora
Nayak PA, et al.
Clinical, cosmetic and investigational dentistry, 6, 89-89 (2014)
Kiet A Ly et al.
Pediatric dentistry, 28(2), 154-163 (2006-05-20)
The purpose of this report was to provide an overview of xylitol and other polyol sweeteners and dental caries for clinicians and to discuss current applications for dental practice and potential community-based public health interventions. Xylitol, like other polyol sweeteners
Lilian Raquel Hickert et al.
Bioresource technology, 143, 112-116 (2013-06-25)
Co-fermentation and simultaneous saccharification of rice hull hydrolysate (RHH) were investigated for the production of ethanol and xylitol by Saccharomyces cerevisiae, Spathaspora arborariae, or the combination of both. In bioreactor cultures under oxygen limitation, S. cerevisiae was capable of metabolizing
Xiaoxiao Guo et al.
Bioresource technology, 128, 547-552 (2012-12-06)
In this study, an integrated xylitol production pathway, directly using xylan as the substrate, was constructed in Candida tropicalis BIT-Xol-1 which could efficiently convert xylose into xylitol. In order to consolidate this bioprocessing, a β-1,4-xylanase gene (atn) and a β-xylosidase

Protocols

Separation of Maltotriose; Maltose; Xylitol

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