PHR1520

Chlortetracycline Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Chlortetracycline hydrochloride, 7-Chlorotetracycline hydrochloride
• Empirical Formula (Hill Notation): C₂₂H₂₃ClN₂O₈ · HCl
• CAS Number: 64-72-2
• Molecular Weight: 515.34
• Beilstein/REAXYS Number: 3858364
• EC Number: 200-591-7
• MDL number: MFCD00082440
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823435
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to BP 783; traceable to Ph. Eur. C2000000; traceable to USP 1129007
• API family: chlortetracycline
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 210-215 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: -10 to -25°C
• SMILES string: Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O
• InChI: 1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1
• InChI key: CBHYYLPALVVVEY-LYNLVHCPSA-N

Description

General description

Chlortetracycline Hydrochloride is a salt of chlortetracycline, which is a tetracycline which shows broad-spectrum antibiotic activity. It is generally used as a veterinary and aquaculture medicine. It is often used on dairy cattle and aquacultured catfish, salmon, and lobster.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlortetracycline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3430 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H315,H317,H319,H335,H361fd
• pcodes: P202 - P261 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable