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PHR1412

Supelco

Chloramphenicol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Chloramphenicol, D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α−(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide
EC Number:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 854
traceable to Ph. Eur. C1200000
traceable to USP 1107004

API family

chloramphenicol

CofA

current certificate can be downloaded

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

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This Item
R4408C0378C7795
vibrant-m

PHR1412

Chloramphenicol

vibrant-m

R4408

Chloramphenicol

vibrant-m

C0378

Chloramphenicol

vibrant-m

C7795

Chloramphenicol

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

-

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

-

grade

-

storage temp.

-10 to -25°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

2-8°C

agency

traceable to BP 854

agency

-

agency

-

agency

-

General description

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is widely used against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Mode of Action:Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription

Mode of Resistance:Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

Suitability

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.

Preparation Note

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA2476 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

CorrosionHealth hazard

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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