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PHR1764

Supelco

Colchicine

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Colchicine, (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
Empirical Formula (Hill Notation):
C22H25NO6
CAS Number:
Molecular Weight:
399.44
Beilstein:
2228813
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 1150
traceable to Ph. Eur. C2580000
traceable to USP 1146006

API family

colchicine, thiocolchicoside

CofA

current certificate can be downloaded

packaging

pkg of 400 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

150-160 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

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This Item
C97541146006C2580000
Colchicine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1764

Colchicine

Colchicine ≥95% (HPLC), powder

Sigma-Aldrich

C9754

Colchicine

Colchicine United States Pharmacopeia (USP) Reference Standard

USP

1146006

Colchicine

Colchicine (European Pharmacopoeia (EP) Reference Standard)

C2580000

Colchicine

packaging

pkg of 400 mg

packaging

-

packaging

-

packaging

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

-

format

neat

format

neat

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron).

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 2 Oral - Muta. 1B

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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25G
Pack Size/Quantity

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Colchicine intoxication: clinical pharmacology, risk factors, features, and management.
Putterman C, et al.
Seminars in Arthritis and Rheumatism, 21(3), 143-155 (1991)
Rapid and sensitive liquid chromatography?tandem mass spectrometry method for the quantitation of colchicine in human plasma
Jiang Y. et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 850(1-2), 564-568 (2007)
Colchicine
Wyatt D K, et al.
Anal. Profiles Drug Subst., 10, 139-182 (1981)

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