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SYNPLE-P004

Sigma-Aldrich

Reagent-cartridge CRBN-PEG4

Synple

Synonym(s):

Synple 2

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500 ML
$206.00

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500 ML
$206.00

About This Item

MDL number:
UNSPSC Code:
12161503
NACRES:
NA.22

$206.00


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ligand

pomalidomide

Quality Level

parameter

up to 0.1 mmol scale

InChI key

HVPZHRHEHKZOOJ-TYBLODHISA-N

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1 of 4

This Item
26909336400289700
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

water: slightly soluble

solubility

-

solubility

-

solubility

-

bp

119-120 °C/17 mmHg (lit.)

bp

128-129 °C/16 mmHg (lit.)

bp

-

bp

135-137 °C/17 mmHg (lit.)

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

−20°C

form

liquid

form

liquid

form

-

form

powder

General description

Reagent-cartridge CRBN-PEG4 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG4
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: amine
Compatible substrates: ketone, aldehyde

Cartridge contents:
  • Reducing agent (supported cyanoborohydride)
  • Base (supported triethylamine)
  • SCX (for purification)
  • Degrader building block linker reagent

Related Cartridges:
  • SYNPLE-P001Reagent-cartridge CRBN-PEG1
  • SYNPLE-P002Reagent-cartridge CRBN-PEG2
  • SYNPLE-P003Reagent-cartridge CRBN-PEG3
  • SYNPLE-P005Reagent-cartridge CRBN-PEG5
  • SYNPLE-P021Reagent-cartridge VHL-PEG1
  • SYNPLE-P022Reagent-cartridge VHL-PEG2
  • SYNPLE-P023Reagent-cartridge VHL-PEG3
  • SYNPLE-P024Reagent-cartridge VHL-PEG4
  • SYNPLE-P025Reagent-cartridge VHL-PEG5

Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks

Features and Benefits of Synple Platform
  • Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
  • Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
  • Safety - all chemicals are contained in the system, minimizing the user′s exposure
  • Set-up reaction in less than 5 minutes
  • Small footprint
  • Plug & Play system - simple installation
  • Reaction temperatures from 25 °C - 80 °C
  • Cartridges available for many different reactions
  • Prefilled with all required reagents
  • RFID chip containing optimized reaction protocol

Legal Information

Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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    Articles

    Protein Degrader Building Blocks are a collection of crosslinker-E3 ligand conjugates with a pendant functional group for covalent linkage to a target ligand.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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