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Y0001665

Progesterone for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Progesterone, 4-Pregnene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
57-83-0
Molecular Weight:
314.46
Beilstein/REAXYS Number:
1915950
MDL number:
MFCD00003658
UNSPSC Code:
41116107
PubChem Substance ID:
329831528
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

progesterone

manufacturer/tradename

EDQM

mp

128-132 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

Gene Information

human ... PGR(5241)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Progesterone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Steroid hormone produced by the corpus luteum.
Sales restrictions may apply.

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Y0001667

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Progesterone, British Pharmacopoeia (BP) Reference Standard

PHR2280

Progesterone Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2563

11-Ketoprogesterone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8932

(20R)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8933

(17α)-Pregn-4-ene-3,20-dione, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8935

(20S)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8939

(20R)-3-Oxopregn-4-en-20-yl acetate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8943

(20S)-3-Oxopregn-4-en-20-yl acetate

PHR2905

Progesterone Related Compound H, pharmaceutical secondary standard, certified reference material

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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Sigma-Aldrich

P8783

Progesterone

Gunter von Minckwitz et al.
The Lancet. Oncology, 15(7), 747-756 (2014-05-06)
Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy
Brett E Skolnick et al.
The New England journal of medicine, 371(26), 2467-2476 (2014-12-11)
Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase
David W Wright et al.
The New England journal of medicine, 371(26), 2457-2466 (2014-12-11)
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials involving patients with TBI. We conducted a double-blind, multicenter clinical trial
A R Harmer et al.
The Journal of physiology, 592(3), 523-535 (2013-12-04)
Calcium cycling is integral to muscle performance during the rapid muscle contraction and relaxation of high-intensity exercise. Ca(2+) handling is altered by diabetes mellitus, but has not previously been investigated in human skeletal muscle. We investigated effects of high-intensity exercise
Eszter Papp et al.
The Journal of infectious diseases, 211(1), 10-18 (2014-07-18)
Protease inhibitor (PI)-based combination antiretroviral therapy (cART) is administered during pregnancy to prevent perinatal human immunodeficiency virus (HIV) transmission. However, PI use has been associated with adverse birth outcomes, including preterm delivery and small-for-gestational-age (SGA) births. The mechanisms underlying these
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