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PHR1037

Supelco

Thiamine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Aneurine hydrochloride, Vitamin B1 hydrochloride
Empirical Formula (Hill Notation):
C12H17ClN4OS · HCl
CAS Number:
Molecular Weight:
337.27
Beilstein/REAXYS Number:
3851771
EC Number:
MDL number:
eCl@ss:
34058006
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. Y0000467
traceable to USP 1656002

API family

thiamine

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

250 °C (dec.) (lit.)

application(s)

food and beverages

format

neat

storage temp.

2-8°C

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

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1 of 4

This Item
T4625T1270T4562
vibrant-m

PHR1037

Thiamine hydrochloride

-
vibrant-m

T4625

Thiamine hydrochloride

Essential Grade
vibrant-m

T1270

Thiamine hydrochloride

-
vibrant-m

T4562

Thiamine hydrochloride

-
application(s)

food and beverages

application(s)

-

application(s)

agriculture

application(s)

pharmaceutical (small molecule)

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

format

neat

format

-

format

-

format

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

grade

certified reference material, pharmaceutical secondary standard

grade

reagent grade

grade

-

grade

-

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Thiamine hydrochloride belongs to the class of water soluble, B vitamins. It is present most commonly in food-stuffs either in free form or phosphorylated form.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Thiamine hydrochloride may be used as a standard in the determination of thiamine hydrochloride in food samples using high performance liquid chromatographic system coupled with fluorescence detector (HPLC/fluorimetry). It may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB9939 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Related product

Product No.
Description
Pricing

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Reversed-phase high-performance liquid chromatography method with coulometric electrochemical and ultraviolet detection for the quantification of vitamins B1 (thiamine), B6 (pyridoxamine, pyridoxal and pyridoxine) and B12 in animal and plant foods
Lebiedzinska A, et al.
Journal of Chromatography A, 1173, 71-80 (2007)
Extraction procedures for the liquid chromatographic determination of thiamin, riboflavin and vitamin B6 in foodstuffs
Ndaw.S, et al.
Food Chemistry, 71, 129-138 (2000)
High-performance liquid chromatography method for the simultaneous determination of thiamine hydrochloride, pyridoxine hydrochloride and cyanocobalamin in pharmaceutical formulations using coulometric electrochemical and ultraviolet detection
Marszall LM, et al.
Journal of Chromatography A, 1094(1-2), 91-98 (2005)
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Protocols

Separation of Pyridoxine Hydrochloride (B6), analytical standard; Thiamine Hydrochloride (B1), analytical standard

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