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PHR1036

Supelco

Pyridoxine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
3-Hydroxy-4,5-bis (hydroxymethyl)-2-picoline hydrochloride, Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B6 hydrochloride
Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
Molecular Weight:
205.64
Beilstein/REAXYS Number:
3632435
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 458
traceable to Ph. Eur. P4100000
traceable to USP 1587001

API family

pyridoxine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

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This Item
80823P4100000BP458
vibrant-m

PHR1036

Pyridoxine hydrochloride

vibrant-m

80823

Pyridoxine hydrochloride

vibrant-m

P4100000

Pyridoxine hydrochloride

vibrant-m

BP458

Pyridoxine hydrochloride

application(s)

pharmaceutical (small molecule)

application(s)

vitamins, nutraceuticals, and natural products

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

Quality Level

300

Quality Level

300

Quality Level

-

Quality Level

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

General description

Pyridoxine hydrochloride is a water soluble vitamin, widely used for the prevention of peripheral neuropathy and central nervous system effects associated with therapy involving isoniazid. It is highly required for the formation of hemoglobin and is also mainly involved in carbohydrate, fat and amino acid metabolism.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Pyridoxine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and spectrophotometric techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3720 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Pyridoxine Impurity A

Simultaneous derivative spectrophotometric analysis of doxylamine succinate, pyridoxine hydrochloride and folic acid in combined dosage forms
Pathak A and Rajput JS
Indian Journal of Pharmaceutical Sciences, 70(4), 513-513 (2008)
Development and validation of RP-HPLC method for simultaneous determination of pyridoxine hydrochloride, isoniazid, pyrazinamide and rifampicin in pharmaceutical formulation
Dhal KS and Sharma R
Chem. Anal. (Warsaw), 54(6), 1487-1487 (2009)
Vijay P Singh et al.
The Journal of organic chemistry, 78(4), 1478-1487 (2013-01-16)
Vitamin B6 is involved in a variety of enzymatic transformations. Some recent findings also indicate an antioxidant role of the vitamin in biological systems. We set out to turn pyridoxine (1a) into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant by replacing
Manfred Eggersdorfer et al.
Angewandte Chemie (International ed. in English), 51(52), 12960-12990 (2012-12-05)
The discovery of vitamins as essential factors in the diet was a scientific breakthrough that changed the world. Diseases such as scurvy, rickets, beriberi, and pellagra were recognized to be curable with an adequate diet. These diseases had been prevalent
Liat Ashkenazi-Hoffnung et al.
The Israel Medical Association journal : IMAJ, 15(1), 23-26 (2013-03-15)
Diclectin (pyridoxine 10 mg and doxylamine 10 mg) has traditionally been used to treat nausea and vomiting of pregnancy (NVP); however, this drug is unavailable in many countries. To evaluate the efficacy and safety of a simple bi-daily treatment regimen

Protocols

Separation of Pyridoxine Hydrochloride (B6), analytical standard; Thiamine Hydrochloride (B1), analytical standard

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