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PHR1337

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Thiamine Nitrate

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Thiamine nitrate, Vitamin B1 nitrate
Empirical Formula (Hill Notation):
C12H17N5O4S
CAS Number:
Molecular Weight:
327.36
Beilstein/REAXYS Number:
3857790
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to BP 414
traceable to Ph. Eur. Y0000060

API family

thiamine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[O-][N+]([O-])=O.CC1=NC=C(C[N+]2=CSC(CCO)=C2C)C(N)=N1

InChI

1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1

InChI key

UIERGBJEBXXIGO-UHFFFAOYSA-N

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PHR1037PHR1369PHR1033
Thiamine Nitrate Pharmaceutical Secondary Standard; Certified Reference Material

PHR1337

Thiamine Nitrate

Thiamine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

PHR1037

Thiamine hydrochloride

Thiamine pyrophosphate Pharmaceutical Secondary Standard; Certified Reference Material

PHR1369

Thiamine pyrophosphate

Niacinamide Pharmaceutical Secondary Standard; Certified Reference Material

PHR1033

Niacinamide

format

neat

format

neat

format

neat

format

neat

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-30°C

agency

traceable to BP 414

agency

traceable to Ph. Eur. Y0000467, traceable to USP 1656002

agency

traceable to USP 1656002

agency

traceable to BP 460, traceable to Ph. Eur. N0600000, traceable to USP 1462006

General description

Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine Nitrate is a mononitrate salt of thiamine. It is synthesized from thiamine hydrochloride following a sequence of steps. Thiamine Nitrate is used as a dietary supplement in crackers, eggs substitute and enriched flour.

application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3016 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Encyclopedia of Food and Color Additives, 3 (1997)
Food Additives Handbook (1989)
Encyclopedia of Food and Color Additives, 3 (1997)
Gloria Uccello-Barretta et al.
Journal of pharmaceutical and biomedical analysis, 107, 7-10 (2015-01-07)
In total parenteral nutrition (TPN), especially in the case of preterm infants, simultaneous administration of vitamins and trace elements is still a problematic issue: guidelines put in evidence the lack of specific documentation. In this work NMR spectroscopy was applied

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