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PHR1035

Supelco

Folic acid

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, PteGlu, Pteroyl-L-glutamic acid, Vitamin M
Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
Molecular Weight:
441.40
Beilstein/REAXYS Number:
100781
EC Number:
MDL number:
eCl@ss:
34058014
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. F0300000
traceable to USP 1286005

API family

folic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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This Item
F7876F8758F8798
vibrant-m

PHR1035

Folic acid

vibrant-m

F7876

Folic acid

vibrant-m

F8758

Folic acid

vibrant-m

F8798

Folic acid

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

technique(s)

-

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

200

storage temp.

2-30°C

storage temp.

room temp

storage temp.

room temp

storage temp.

-

grade

certified reference material, pharmaceutical secondary standard

grade

-

grade

-

grade

-

agency

traceable to Ph. Eur. F0300000

agency

-

agency

-

agency

USP/NF, meets USP testing specifications

General description

Folic acid is mostly obtained from the diet itself or from pharmaceutical drugs such as vitamin pills.† It is highly necessary to consume folic acid for the prevention of neural tube defects, mainly anencephaly and spina bifida.† It belongs to the class of water soluble B vitamins called folates. It is mainly used to fortify cereals/grains and dietary supplements.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Folic acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using ultraviolet spectrophotometric technique and microemulsion electrokinetic chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7352 in the slot below. This is an example certificate only and may not be the lot that you receive.

Related product

Product No.
Description
Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Quantitative determination of folic acid in multivitamin/multielement tablets using liquid chromatography/tandem mass spectrometry
Nelson.CB, et al.
Journal of Chromatography A, 1135, 203-211 (2006)
A UV spectrophotometric method for the determination of folic acid in pharmaceutical tablets and dissolution tests
Matias R, et al.
Analytical Methods : Advancing Methods and Applications, 6(9), 3065-3071 (2014)
Determination of folic acid in tablets by microemulsion electrokinetic chromatography
Aurora-Prado SM, et al.
Journal of Chromatography A, 1051(1-2), 291-296 (2004)
Andrew J Copp et al.
The Lancet. Neurology, 12(8), 799-810 (2013-06-25)
Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come from the finding that closure of open spina bifida lesions in utero can diminish neurological dysfunction in children. Primary
Breige McNulty et al.
The American journal of clinical nutrition, 98(1), 92-98 (2013-05-31)
Supplementation with folic acid (FA) is recommended worldwide before and during early pregnancy because of its proven effect in preventing neural tube defects, but the role of FA after the 12th gestational week (GW) is much less clear. We investigated

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