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27001

Sigma-Aldrich

Formic acid

puriss., meets analytical specifications of DAC, FCC, 98.0-100%

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Linear Formula:
HCOOH
CAS Number:
Molecular Weight:
46.03
Beilstein/REAXYS Number:
1209246
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.21

agency

suitable for EPA 1633

Quality Level

vapor density

1.6 (vs air)

vapor pressure

44.8 mmHg ( 20 °C)

grade

puriss.

assay

98.0-100%

form

liquid

autoignition temp.

1004 °F

quality

meets analytical specifications of DAC, FCC

expl. lim.

57 %

technique(s)

HPLC: suitable

impurities

≤0.001% heavy metals (as Pb)
≤0.005% non-volatile matter
≤0.05% acetic acid (GC)

refractive index

n20/D 1.370 (lit.)

pH

2.2 (20 °C, 2.2 g/L)

bp

100-101 °C (lit.)

mp

8.2-8.4 °C (lit.)

density

1.22 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤10 mg/kg
sulfate (SO42-): ≤40 mg/kg
sulfite (SO32-): ≤50 mg/kg

cation traces

Fe: ≤0.001%
heavy metals (as Pb): ≤0.001%

SMILES string

OC=O

InChI

1S/CH2O2/c2-1-3/h1H,(H,2,3)

InChI key

BDAGIHXWWSANSR-UHFFFAOYSA-N

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Application


  • Evaluation of aloins, pH and moisture in aloe leaf gel-based personal care products.: This research assessed the consistency and quality of aloe-based products using advanced analytical chemistry techniques, including formic acid in sample preparation to stabilize pH levels and enhance detection accuracy (Sibhat et al., 2022).

  • Multi-Residue Analysis of Fipronil and Its Metabolites in Eggs by SinChERS-Based UHPLC-MS/MS.: Describes the use of formic acid in the sample preparation phase to improve the extraction and detection of pesticide residues, demonstrating its pivotal role in ensuring food safety (Han et al., 2021).

  • Simultaneous determination of phenolic acids and flavonoids in Artemisiae Argyi Folium by HPLC-MS/MS and discovery of antioxidant ingredients based on relevance analysis.: Illustrates how formic acid was essential for modifying the mobile phase in chromatography, enhancing the resolution and quantification of bioactive compounds (Xia et al., 2019).

  • Evaluation of three different artificial agarwood-inducing methods from Aquilaria sinensis using antimicrobial activity.: This study used formic acid in antimicrobial assays to compare the efficacy of different agarwood induction techniques, highlighting its versatility in bioactive compound analysis (Lei et al., 2019).

  • Chemical Analysis and Multi-Component Determination in Chinese Medicine Preparation Bupi Yishen Formula Using Ultra-High Performance Liquid Chromatography With Linear Ion Trap-Orbitrap Mass Spectrometry and Triple-Quadrupole Tandem Mass Spectrometry.: Showcases the application of formic acid in the complex analysis of traditional Chinese medicine, enabling precise quantification and identification of multiple components simultaneously (Zhang et al., 2018).


Other Notes

The article number 27001-4X2.5L-M will be discontinued. Please order the single bottle 27001-2.5L-M which is physically identical with the same exact specifications.
The article number 27001-4X2.5L-R will be discontinued. Please order the single bottle 27001-2.5L-R which is physically identical with the same exact specifications.
The article number 27001-6X1L-R will be discontinued. Please order the single bottle 27001-1L-R which is physically identical with the same exact specifications.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

supp_hazards

wgk_germany

WGK 1

flash_point_f

closed cup

flash_point_c

closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Oxidation of formic acid in acid solution on Pt single-crystal electrodes.
Kita H and Lei H-W.
Journal of Electroanalytical Chemistry, 388(1), 167-177 (1997)
Elastic electron scattering from formic acid (HCOOH): absolute differential cross-sections.
Vizcaino V, et al.
New Journal of Physics, 8(6), 85-85 (2006)
Crossover of formic acid through Nafion membranes.
Rhee Y-W, et al.
Journal of Power Sources, 117(1), 35-38 (2003)
Heng Lu et al.
Cell communication insights, 5, 1-7 (2014-05-20)
Protein-protein interactions play a pivotal role in both inter- and intra-cellular signaling. Identification of signaling protein complexes can thus shed important new insights into cell communications. We developed a parallel affinity precipitation protocol to overcome the disadvantages of the tandem
J Liesivuori et al.
Pharmacology & toxicology, 69(3), 157-163 (1991-09-01)
Metabolism of methanol, methyl ethers, esters and amides give rise to formic acid. This acid is an inhibitor of the mitochondrial cytochrome oxidase causing histotoxic hypoxia. Formic acid is a weaker inhibitor than cyanide and hydrosulphide anions. The body burden

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