375810

Periodic acid

ACS reagent, 99%

• Empirical Formula (Hill Notation): H₅IO₆
• CAS Number: 10450-60-9
• Molecular Weight: 227.94
• EC Number: 233-937-0
• MDL number: MFCD00011344
• UNSPSC Code: 12352106
• PubChem Substance ID: 329755660
• NACRES: NA.21

Properties

• grade: ACS reagent
• assay: 99%; 99.0-101.0% (ACS specification)
• form: powder or crystals
• reaction suitability: reaction type: C-H Activation; reagent type: catalyst; reagent type: oxidant
• impurities: ≤0.01% insolubles; ≤0.01% other halogens
• ign. residue: ≤0.01%
• mp: 122 °C (lit.)
• solubility: water: soluble
• anion traces: sulfate (SO₄^2-): ≤0.01%
• cation traces: Fe: ≤0.003%; heavy metals: ≤0.005%
• application(s): histology
• SMILES string: OI(O)(O)(O)(O)=O
• InChI: 1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
• InChI key: TWLXDPFBEPBAQB-UHFFFAOYSA-N

Description

General description

Periodic acid is an inorganic acid commonly used as an oxidizing agent. Periodic acid oxidation is one of the steps in the periodate-resorcinol assay, used in the determination of sialic acid. Periodic acid reacts with 1,2 glycol linkage of carbohydrates to form aldehydes which can be stained by Schiff′s reagent. Therefore periodic-acid-Schiff′s reagent (PAS) is used in histochemistry to determine carbohydrates in tissue sections.

Application

Periodic acid may be used in the following reactions:

• Oxidation of alcohols to ketones and aldehydes.
• Oxidation hydroxylamine derivatives.
• Oxidation of arenes to quinones.
• Deprotection of the dithio- and oxathio-derivatives.
• Oxidative degradation of epoxidized natural rubber (ENR).
• Oxidation of urazoles and bis-urazoles to triazolinediones.
• Oxidative cleavage of glucosazone.

Safety Information

• pictograms: GHS03,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H271,H314,H372,H410
• pcodes: P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
• target_organs: Thyroid
• Storage Class: 5.1A - Strongly oxidizing hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable