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29311

Sigma-Aldrich

CHES

BioUltra, ≥99.5% (T)

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Synonym(s):
2-(Cyclohexylamino)ethanesulfonic acid
Empirical Formula (Hill Notation):
C8H17NO3S
CAS Number:
Molecular Weight:
207.29
Beilstein/REAXYS Number:
2967601
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

product line

BioUltra

Quality Level

assay

≥99.5% (T)

form

powder

impurities

insoluble matter, passes filter test

ign. residue

≤0.05%

loss

≤0.5% loss on drying, 110 °C

pH

3.0-5.0 (25 °C, 0.5 M in H2O)

useful pH range

8.6-10.0

pKa (25 °C)

9.3

solubility

H2O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

0.5 M in H2O

UV absorption

λ: 260 nm Amax: 0.08
λ: 280 nm Amax: 0.05

SMILES string

OS(=O)(=O)CCNC1CCCCC1

InChI

1S/C8H17NO3S/c10-13(11,12)7-6-9-8-4-2-1-3-5-8/h8-9H,1-7H2,(H,10,11,12)

InChI key

MKWKNSIESPFAQN-UHFFFAOYSA-N

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C2885C8210C6013
CHES BioUltra, ≥99.5% (T)

29311

CHES

Premium Grade
CHES ≥99.0% (titration)

C2885

CHES

-
CHES BioXtra, ≥99.0% (titration)

C8210

CHES

Premium Grade
Cholesteryl hemisuccinate tris salt anionic detergent

C6013

Cholesteryl hemisuccinate tris salt

-
product line

BioUltra

product line

-

product line

BioXtra

product line

-

form

powder

form

crystalline

form

powder

form

powder

pH

3.0-5.0 (25 °C, 0.5 M in H2O)

pH

3.0-5.0 (103.6 g/L)

pH

3.0-5.0 (0.5 M in H2O)

pH

-

solubility

H2O: 0.5 M at 20 °C, clear, colorless

solubility

water: 0.6 g/25 mL, clear, colorless

solubility

H2O: 0.5 M, clear, colorless

solubility

-

impurities

insoluble matter, passes filter test

impurities

-

impurities

≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter

impurities

-

General description

Cyclohexylaminoethanesulfonic acid (CHES) is a buffering agent. Its structure contains a hydrophilic taurine (2-aminoethanesulfonic acid) moiety and a hydrophobic cyclohexyl group. CHES binds to the active site of several enzymes and inhibits substrate binding and enzymatic activity. Therefore, CHES may be used as a scaffold for new drug development for regulating enzyme activity.

Application

2-(Cyclohexylamino)ethanesulfonic acid (CHES) has been used in the preparation of dimethyl trisulfide- polysorbate 80 (DMTS-PS80) formulation.

Other Notes

Buffer for studying pH-dependent processes in enzymology; Has a high affinity for the iodoacetate binding site of liver alcohol dehydrogenase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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C Syvertsen et al.
European journal of biochemistry, 117(1), 165-170 (1981-06-01)
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