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31392

Sigma-Aldrich

Dextran from Leuconostoc spp.

Mr 450,000-650,000

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Synonym(s):
6-O-(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-D-glucose, Manninotriose
Linear Formula:
(C6H10O5)n
CAS Number:
EC Number:
MDL number:
NACRES:
NA.25

biological source

(Leuconostoc spp)

form

powder

mol wt

Mr 450,000-650,000

technique(s)

cell based assay: suitable

loss

≤7% loss on drying

color

white

mp

483  °C ((901 °F ))

solubility

water: 1.5 g/10 mL, clear, colorless

absorption

≤0.05 at 375 nm in H2O at 10%

suitability

suitable for additive or modifier in the separation of proteins or peptides
suitable for microfluidics/nanofluidics

application(s)

clinical research
filtration
life science and biopharma
metabolomics
plasma purification

storage temp.

room temp

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2

InChI key

FZWBNHMXJMCXLU-UHFFFAOYSA-N

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This Item
313903138831387
vibrant-m

31392

Dextran from Leuconostoc spp.

vibrant-m

31390

Dextran from Leuconostoc spp.

vibrant-m

31388

Dextran from Leuconostoc spp.

vibrant-m

31387

Dextran from Leuconostoc spp.

technique(s)

cell based assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

solubility

water: 1.5 g/10 mL, clear, colorless

solubility

water: 0.75 g/5mL, clear

solubility

water: 1.5 g/10 mL, colorless to faintly yellow

solubility

water: 0.5 g/5mL, colorless

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

suitability

suitable for additive or modifier in the separation of proteins or peptides, suitable for microfluidics/nanofluidics

suitability

-

suitability

-

suitability

-

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

General description

Dextran, a biodegradable bacterial exopolysaccharide, is a member of the polysaccharide family predominantly composed of glucose units linked through α-(1→6) bonds in the main chain, often with α-(1→2), α-(1→3), and α-(1→4) branching. This versatile compound is typically derived from lactic acid bacteria like Leuconostoc, Lactobacillus, Streptococcus, Weissella, and Pediococcus, presenting a molecular weight range from 1,000 to 40,000,000 daltons (Da). The specific structure of dextran varies depending on the microbial strain responsible for its production. Dextran exhibits solubility in water and in few organic solvents and can be chemically modified to create diverse structures such as spheres, tubes, and 3D networks. This adaptability allows dextran to be blended with bioactive agents or hydrophobic polymers for various applications. With its remarkable water solubility, biocompatibility, and non-toxic properties, dextran serves as a valuable molecular scaffold, solute stabilizer, and cryoprotectant in cell culture and bioprocessing. These attributes make dextrans essential in a wide array of biomedical fields, including cell culture, drug delivery, nanomedicine, and various applications within the realm of biochemical research.

Application

Dextran from Leuconostoc spp. has been used:

  • in the isolation of human neutrophils from blood samples
  • for blood sedimentation
  • in the resuspension of human umbilical vein cells (HUVECs) for 3D microfluidic cellular adhesion assay
  • in studying aqueous two-phase system (ATPS) droplets In microfluidic systems and biocompatible applications
  • to study its mechanical properties through single-molecule force spectroscopy

Biochem/physiol Actions

Dextran′s mechanism of action for various applications:

  • Osmotic Balance: Dextran helps maintain osmotic balance by increasing the solute concentration in a solution. This prevents excessive water movement across cell membranes, thus maintaining cell integrity and function.
  • Cryoprotection: Dextran acts as a cryoprotectant by forming a protective barrier around cells and tissues during freezing. This barrier inhibits the formation of ice crystals, which can damage cell membranes and structures.
  • Viscosity Control: Dextran can alter the viscosity of solutions by increasing the molecular weight of the solution. This change in viscosity affects the flow properties of the solution, making it useful for controlling the thickness of solutions in various processes.
  • Drug Delivery: Modified dextran serves as a carrier for controlled drug delivery. Dextran can encapsulate drugs and release them gradually, enhancing drug solubility and controlling the release profiles to improve therapeutic outcomes.
  • Gel Electrophoresis: Dextran increases the density of sample-loading solutions in gel electrophoresis. This increased density helps samples sink into the gel matrix, allowing for more precise separation of molecules based on size and charge during electrophoresis.
  • Enzyme Stabilization: Dextran stabilizes enzymes by providing a protective environment. It forms a stable matrix around enzymes, enhancing their activity and extending their lifespan in various biochemical reactions. This protection prevents enzyme denaturation and inactivation, allowing enzymes to function more effectively.

Features and Benefits

  • Dextran with an average molecular weight range of 450,000-650,000
  • Freely soluble in Water, DMSO, formamide, ethylene glycol, and glycerol
  • Versatile and adaptable for wide variety of laboratory and research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)


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Customers Also Viewed

Slide 1 of 7

1 of 7

Single-Molecule Force Spectroscopy of Dextran. In: Correlation Force Spectroscopy for Single Molecule Measurements
Radiom, M
Springer Science Reviews, 81, 71-71 (2015)
Peng Kai Ong et al.
American journal of physiology. Heart and circulatory physiology, 298(6), H1870-H1878 (2010-03-30)
Formation of a cell-free layer is an important dynamic feature of microcirculatory blood flow, which can be influenced by rheological parameters, such as red blood cell aggregation and flow rate. In this study, we investigate the effect of these two
Water-head-driven microfluidic oscillators for autonomous control of periodic flows and generation of aqueous two-phase system droplets
Dang et al.
Lab on a chip, 17, 286-292 (2017)
Robert E Sealy et al.
International immunology, 28(11), 559-564 (2016-10-30)
Antibody-secreting cells (ASCs) in respiratory tract tissues provide a first line of defense against invading pathogens. These cells often secrete IgA that is efficiently transcytosed across epithelial barriers into the airway lumen where pathogens can be blocked at their point
Aude Thiriot et al.
BMC biology, 15(1), 45-45 (2017-05-21)
Intravascular leukocyte recruitment in most vertebrate tissues is restricted to postcapillary and collecting venules, whereas capillaries and arterioles usually support little or no leukocyte adhesion. This segmental restriction is thought to be mediated by endothelial, rather than hemodynamic, differences. The

Related Content

Learn about C6H10O6 or dextran formation, classes and naming. Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, which have a linear backbone of α-linked d-glucopyranosyl repeating units.

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