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325M-1

Sigma-Aldrich

CA-125 (OC125) Mouse Monoclonal Antibody

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NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

OC125, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (325M-14)
vial of 0.5 mL concentrate (325M-15)
bottle of 1.0 mL predilute (325M-17)
vial of 1.0 mL concentrate (325M-16)
bottle of 7.0 mL predilute (325M-18)

manufacturer/tradename

Cell Marque

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1κ

control

ovarian carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... MUC16(94025)

General description

CA-125 (cancer antigen 125) is a large transmembrane glycoprotein belonging to the mucin family, encoded by the gene MUC16. By immunohistochemistry, CA-125 expression is not identified in normal ovarian tissue, but it is found in the normal cervix, fallopian tube, and endometrium. Positive immunostaining for CA-125 is seen in most ovarian carcinomas and epithelioid mesotheliomas.
Anti-CA-125 antibody reacts with epithelioid malignancies of the ovary, papillary serous carcinoma of the cervix, adenocarcinoma of the endometrium, clear cell adenocarcinoma of the bladder, and epithelioid mesothelioma. The antigen is formalin resistant, permitting the detection of ovarian cancer by immunohistochemistry, although serum assays for this protein are widely used to monitor ovarian cancer. Anti-CA-125 also reacts with antigens in seminal vesicle carcinoma.

Quality


IVD

IVD

IVD

RUO

Linkage

CA-125 Positive Control Slides, Product No. 325S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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