478M-9

CDK4 (DCS-31) Mouse Monoclonal Antibody

• UNSPSC Code: 12352203

Properties

• biological source: mouse
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: DCS-31, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (478M-94); vial of 0.1 mL concentrate Research Use Only (478M-94-RUO); vial of 0.5 mL concentrate (478M-95); vial of 1.0 mL concentrate (478M-96); vial of 1.0 mL concentrate Research Use Only (478M-96-RUO); vial of 1.0 mL pre-dilute Research Use Only (478M-97-RUO); vial of 1.0 mL pre-dilute ready-to-use (478M-97); vial of 7.0 mL pre-dilute ready-to-use (478M-98); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (478M-98-RUO)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• isotype: IgG
• control: dedifferentiated liposarcoma, well-differentiated liposarcoma
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear

Description

General description

Well-differentiated liposarcoma is a malignant, non-metastasizing tumor that can present with similar histological characteristics as benign lipoma lesions and has a higher recurrence rate. The CDK4 protein is frequently overexpressed in well-differentiated liposarcoma due to gene amplification of the 12q13-15 chromosomal region that harbors the CDK4 gene, but amplification and subsequent overexpression is rarely observed in lipomas. Due to CDK4 protein expression differences between these lesions, anti-CDK4 antibody can be used in an immunohistochemistry panel as an aid in the differential diagnosis between well-differentiated liposarcoma and lipoma.^1,2,3

Quality

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

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Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany