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H7904

Sigma-Aldrich

(Z)-4-Hydroxytamoxifen

≥98% Z isomer

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Synonym(s):
4OH-Tamoxifen, (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol, (Z)-4-OHT, trans-4-Hydroxytamoxifen
Empirical Formula (Hill Notation):
C26H29NO2
CAS Number:
Molecular Weight:
387.51
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

storage condition

desiccated
protect from light

solubility

methanol: 10 mg/mL
ethanol: 20 mg/mL (with heating)

antibiotic activity spectrum

neoplastics

mode of action

enzyme | inhibits

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3

InChI

1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-

InChI key

TXUZVZSFRXZGTL-QPLCGJKRSA-N

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1 of 4

This Item
H62785790025.08225
vibrant-m

H7904

(Z)-4-Hydroxytamoxifen

vibrant-m

H6278

4-Hydroxytamoxifen

vibrant-m

579002

Tamoxifen, 4-Hydroxy-, (Z)-

vibrant-m

5.08225

(Z)-4-Hydroxytamoxifen

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (HPLC)

assay

≥99% (HPLC)

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

100

originator

AstraZeneca

originator

AstraZeneca

originator

-

originator

-

storage condition

desiccated, protect from light

storage condition

desiccated, protect from light

storage condition

OK to freeze

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−70°C

Application

(Z)-4-Hydroxytamoxifen has been used:
  • as a media supplement to study the cell viability by WST-1 Assay
  • for inducing deletion of transforming growth factor-β (TGF-β gene in mice
  • to induce Cre recombinase activity in vitro.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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